INT215611

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.18
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neurons 4
cerebral cortex 2
brainstem 2
patterning 2
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 311 100.00 Very High Very High Very High
depression 74 100.00 Very High Very High Very High
gABA 50 99.36 Very High Very High Very High
cerebral cortex 2 98.44 Very High Very High Very High
medulla 58 98.24 Very High Very High Very High
Neuronal excitability 22 95.12 Very High Very High Very High
agonist 75 91.04 High High
Hippocampus 28 89.84 High High
Dopamine 18 88.32 High High
Substantia nigra 10 86.40 High High
Disease Link Frequency Relevance Heat
Depression 78 100.00 Very High Very High Very High
Hypoxia 39 99.04 Very High Very High Very High
Heart Rate Under Development 19 90.12 High High
Cv Unclassified Under Development 4 85.36 High High
Targeted Disruption 4 81.20 Quite High
Convulsion 28 37.12 Quite Low
Ataxia 4 29.76 Quite Low
Neurological Disease 10 21.84 Low Low
Stress 8 20.24 Low Low
Necrosis 2 8.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, activation of A1AR by adenosine causes an inhibition of adenylate cyclase, which results in decreased intracellular levels of cAMP [35].
Negative_regulation (inhibition) of Positive_regulation (activation) of A1AR associated with adenocard
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.24 Pain Relevance 0.33
Activation of A1Rs inhibited the activity of inspiratory neurons in the brainstem by opening KATP in neonatal mice [123].
Negative_regulation (inhibited) of Positive_regulation (Activation) of A1R in brainstem associated with medulla
2) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.62
Activation of A1Rs inhibits the release of GABA from the ischemic cerebral cortex in vivo [106].
Negative_regulation (inhibits) of Positive_regulation (Activation) of A1R in cerebral cortex associated with gaba and cerebral cortex
3) Confidence 0.41 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.46 Pain Relevance 0.81
This study further demonstrates that during its depression of preBötC rhythmogenesis A1R activation decreases synaptic input to preBötC neurons and alters resting membrane properties in a manner consistent with decreased neuronal excitability.
Negative_regulation (depression) of Positive_regulation (activation) of A1R in neurons associated with neuronal excitability and depression
4) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.16 Pain Relevance 0.19
Activation of A1R depresses preBötC rhythmogenesis similarly in slice and island preparations, the latter representing a condition of reduced synaptic transmission.
Negative_regulation (depresses) of Positive_regulation (Activation) of A1R
5) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.06 Pain Relevance 0.03
Although GABAAergic and glycinergic transmission affect the patterning and excitability of the respiratory network within in vitro preparations from neonatal mammals, the data presented herein show that the depression of preBötC rhythmogenesis by A1R activation is unaffected by reducing the overall level of synaptic input received by preBötC neurons, or by antagonizing GABAA or GABAA and glycine receptors.
Negative_regulation (depression) of Positive_regulation (activation) of A1R in patterning associated with depression
6) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.16 Pain Relevance 0.08
During the present study A1R activation decreased the Rin of preBötC neurons regardless of whether or not those neurons were synaptically isolated from the rest of the network.
Spec (whether) Negative_regulation (decreased) of Positive_regulation (activation) of A1R in neurons
7) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.10 Pain Relevance 0.10

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