INT21565

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Context Info
Confidence 0.17
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.89
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Anatomy Link Frequency
colon 2
brain 1
Ikbkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1 100.00 Very High Very High Very High
Opioid 1 99.96 Very High Very High Very High
aspirin 5 98.80 Very High Very High Very High
cINOD 14 98.08 Very High Very High Very High
Inflammation 58 97.84 Very High Very High Very High
Kappa opioid receptor 1 95.16 Very High Very High Very High
cytokine 23 74.08 Quite High
Enkephalin 3 72.52 Quite High
Immobilon 1 71.52 Quite High
dexamethasone 2 65.28 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 52 99.84 Very High Very High Very High
Rectal Cancer 46 99.04 Very High Very High Very High
INFLAMMATION 61 97.84 Very High Very High Very High
Cancer 18 93.28 High High
Pressure And Volume Under Development 5 76.24 Quite High
Rheumatoid Arthritis 7 54.88 Quite High
Colitis 1 43.68 Quite Low
Disease 19 40.92 Quite Low
Necrosis 1 35.36 Quite Low
Hypersensitivity 6 23.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For independent SNP associations, we observed associations with IL6 and IKBKB in colon cancer but not rectal cancer.
IKBKB Binding (associations) of in colon associated with rectal cancer and colon cancer
1) Confidence 0.17 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 1.06 Pain Relevance 0.29
In a series of publications, Murata and coworkers have disclosed optimization of substituted pyridines to identify compound 6 with IKK2 IC50?
IKK2 Binding (compound) of
2) Confidence 0.17 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.15 Pain Relevance 0.10
Our findings suggest that polymorphisms in IKBKB, IL6, and NFKB1 may jointly interact to influence colon and rectal cancer risk through an inflammation-related pathway.
IKBKB Binding (interact) of in colon associated with inflammation and rectal cancer
3) Confidence 0.12 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0.44 Pain Relevance 0.10
Characterization of kappa 1 and kappa 2 opioid binding sites in frog (Rana esculenta) brain membrane preparation.
kappa 2 Binding (Characterization) of in brain associated with narcan and opioid
4) Confidence 0.04 Published 1990 Journal Neurochem. Res. Section Title Doc Link 2177154 Disease Relevance 0 Pain Relevance 0.48
Whereas the inhibition of nuclear factor-kappaB by aspirin and sodium salicylate can be partly accounted for by their binding to IkappaB kinase-beta, the broad range of transcriptional targets of NSAID suggests that the products of COX activity might affect one or more among the early steps in the TCR-signaling cascade.
IkappaB kinase-beta Binding (binding) of associated with aspirin and cinod
5) Confidence 0.00 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11700329 Disease Relevance 0.24 Pain Relevance 0.68

General Comments

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