INT215650

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1, Drd1a) endoplasmic reticulum (Adora1, Drd1a) plasma membrane (Adora1, Drd1a)
signal transducer activity (Adora1, Drd1a) nucleus (Drd1a) intracellular (Drd1a)
Adora1 (Mus musculus)
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 97 100.00 Very High Very High Very High
Dopamine 13 100.00 Very High Very High Very High
agonist 29 96.16 Very High Very High Very High
psychological dependence 1 85.20 High High
antagonist 20 76.24 Quite High
addiction 28 71.32 Quite High
Eae 2 69.20 Quite High
dopamine receptor 2 59.76 Quite High
Glutamate 14 31.04 Quite Low
Hippocampus 14 25.08 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 1 90.56 High High
Psychosis 48 87.28 High High
Drug Dependence 7 85.20 High High
Disease 6 76.80 Quite High
Targeted Disruption 2 48.96 Quite Low
Hypoxia 8 41.96 Quite Low
Parkinson's Disease 1 41.68 Quite Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results confirmed an antagonistic interaction between A1Rs and D1Rs that had already been observed by Ferré et al. [51] in behavioral studies using reserpinized mice and rabbits.
A1R Binding (interaction) of D1R
1) Confidence 0.39 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.21 Pain Relevance 0.52
Dopamine D1 and D2 receptors exist as heterodimers with adenosine A1 and A2A receptors, respectively, which modulate their responsiveness [9,10], suggesting that responses to amphetamines may also be dependent on adenosinergic function.
adenosine A1 Binding (heterodimers) of Dopamine D1 associated with adenocard and dopamine
2) Confidence 0.00 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2939586 Disease Relevance 0.33 Pain Relevance 0.40

General Comments

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