INT21566

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2008
Negated 2
Speculated 3
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 3.40
Pain Relevance 8.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
plasma 2
dorsal root 1
neuronal 1
neurons 1
brain 1
Oprk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 31 100.00 Very High Very High Very High
addiction 24 100.00 Very High Very High Very High
Dynorphin 16 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
MU agonist 12 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
opioid receptor 6 100.00 Very High Very High Very High
alcohol 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 6 100.00 Very High Very High Very High
INFLAMMATION 9 98.92 Very High Very High Very High
Drug Induced Neurotoxicity 2 98.16 Very High Very High Very High
Coronary Heart Disease 2 95.52 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 4 94.36 High High
Depression 1 92.56 High High
Alcohol Addiction 8 92.08 High High
Cocaine Dependence 4 90.72 High High
Opiate Addiction 6 89.24 High High
Urological Neuroanatomy 9 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of kappa-opioid agonist treatment on kappa-opioid receptor density and on dynorphin A levels in the rat brain were studied.
Regulation (effects) of kappa-opioid receptor in brain associated with mu agonist, dynorphin and kappa opioid receptor
1) Confidence 0.62 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 15456944 Disease Relevance 0.12 Pain Relevance 0.60
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Regulation (Effect) of kappa opioid receptor in plasma associated with narcan, agonist and kappa opioid receptor
2) Confidence 0.45 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 2996912 Disease Relevance 0 Pain Relevance 0.63
The effect of several mu and kappa opioid receptor agonists on rat plasma corticosterone levels, measured using radioimmunoassay, was investigated.
Spec (investigated) Regulation (effect) of kappa opioid receptor in plasma associated with agonist and kappa opioid receptor
3) Confidence 0.45 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2996912 Disease Relevance 0 Pain Relevance 0.53
Differential time course of effects of kappa-opioid agonist treatment on dynorphin A levels and kappa-opioid receptor density.
Regulation (effects) of kappa-opioid receptor associated with mu agonist, dynorphin, analgesic and kappa opioid receptor
4) Confidence 0.45 Published 2004 Journal J. Mol. Neurosci. Section Title Doc Link 15456944 Disease Relevance 0.29 Pain Relevance 0.91
Kappa-opioid-receptor-mediated regulation of alpha-melanocyte-stimulating hormone secretion and tuberohypophyseal dopaminergic neuronal activity.
Regulation (regulation) of Kappa-opioid-receptor in neuronal associated with opioid
5) Confidence 0.44 Published 1990 Journal Neuroendocrinology Section Title Doc Link 2177159 Disease Relevance 0 Pain Relevance 0.54
Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent.
Regulation (regulation) of kappa-opioid-receptor in dopaminergic neurons associated with opioid
6) Confidence 0.44 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7909142 Disease Relevance 0 Pain Relevance 0.32
Lack of effect of kappa-opioid receptor agonism on long-term methamphetamine-induced neurotoxicity in rats.
Regulation (effect) of kappa-opioid receptor associated with drug induced neurotoxicity, analgesic and kappa opioid receptor
7) Confidence 0.42 Published 2003 Journal Neurotox Res Section Title Doc Link 12835119 Disease Relevance 0.24 Pain Relevance 0.47
The kappa opioid antagonist nor-binaltorphamine affected more neurons in rats with inflammation than in control rats.
Neg (nor) Regulation (affected) of kappa opioid in neurons associated with inflammation, antagonist and opioid
8) Confidence 0.40 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8287195 Disease Relevance 0.48 Pain Relevance 0.63
Selective mu-opioid receptor antagonist CTAP completely abolished, while selective delta- and kappa-opioid receptor antagonists did not modulate the antiarrhythmic effect of adaptation.
Neg (not) Regulation (modulate) of kappa-opioid receptor associated with antagonist, kappa opioid receptor and opioid receptor
9) Confidence 0.27 Published 2005 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 16027798 Disease Relevance 0.51 Pain Relevance 0.57
We determined the effects of morphine on mRNA levels for the opioid ligands preprodynorphin (PPD) and preproenkephalin (PPE) and the kappa opioid receptor (KOR).
Spec (determined) Regulation (effects) of kappa opioid receptor associated with kappa opioid receptor, opioid and morphine
10) Confidence 0.25 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10095091 Disease Relevance 0 Pain Relevance 0.70
We have investigated the effects of specific mu-, kappa-and delta-opioid receptor agonists and antagonists on the hypothalamic noradrenergic neurotransmission and on luteinising hormone (LH) release in the ovariectomised and steroid-primed rat.
Spec (investigated) Regulation (effects) of kappa-and delta-opioid receptor associated with antagonist, agonist and opioid receptor
11) Confidence 0.24 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10372509 Disease Relevance 0.07 Pain Relevance 0.45
Compounds acting on the kappa opioid receptor had only weak and inconsistent inhibitory effects on the dorsal root potential.
Regulation (acting) of kappa opioid receptor in dorsal root associated with kappa opioid receptor
12) Confidence 0.14 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3037417 Disease Relevance 0.09 Pain Relevance 1.25
The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.
Regulation (modulates) of OPRK1 associated with drug dependence, addiction and alcohol
13) Confidence 0.13 Published 2008 Journal Mol. Psychiatry Section Title Doc Link 17622222 Disease Relevance 1.59 Pain Relevance 1.02

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