INT215660

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.95
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Alpl) extracellular space (Alpl) plasma membrane (Alpl)
Anatomy Link Frequency
stem cell 3
liver 1
face 1
Alpl (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 13 93.84 High High
Neurotransmitter 12 51.72 Quite High
addiction 2 50.00 Quite Low
cytokine 6 48.48 Quite Low
Pain 6 42.64 Quite Low
depression 2 41.16 Quite Low
noradrenaline 1 34.88 Quite Low
antagonist 18 24.40 Low Low
Glutamate 11 6.40 Low Low
nMDA receptor 1 5.60 Low Low
Disease Link Frequency Relevance Heat
Osteoporosis 67 100.00 Very High Very High Very High
Diabetes Mellitus 157 97.36 Very High Very High Very High
Shock 151 93.76 High High
Embryonal Carcinoma 7 91.36 High High
Congenital Anomalies 4 82.48 Quite High
Targeted Disruption 9 78.36 Quite High
Calcification 49 75.68 Quite High
Hepatotoxicity 1 73.84 Quite High
Renal Disease 5 71.68 Quite High
Disease 29 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akp2, a target gene of Runx2, was significantly down-regulated in insulin-deficient, hyperglycemic diabetic animals along with Runx2 itself and several other targets; however, insulin treatment of diabetic animals significantly restored their expression [44].
Gene_expression (was) of Akp2 associated with diabetes mellitus
1) Confidence 0.57 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.07 Pain Relevance 0
-null mice (Figure 3A), paralleling the increases in gene expression for alkaline phosphatase, liver/bone/kidney (Alpl) after exposure to WY and other PPC (data not shown).
Gene_expression (expression) of Alpl in liver
2) Confidence 0.50 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.81 Pain Relevance 0.05
Transcriptional expressions of several osteoblast-related genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cell markers (ENG) were examined after seven days of treatment with osteoplant.
Spec (examined) Gene_expression (expressions) of ALPL in stem cell associated with osteoporosis
3) Confidence 0.16 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.10 Pain Relevance 0
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, such as, transcriptional factors (RUNX2 and SP7), bone-related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1), and mesenchymal stem cell markers (ENG) were examined, by means of real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR).


Gene_expression (expression) of ALPL in stem cell
4) Confidence 0.16 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.09 Pain Relevance 0
In order to get a better insight into how the osteoplant acts on PB-hMSCs, changes in expression of bone-related marker genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells markers (ENG) were investigated by real-time RT-PCR.
Gene_expression (expression) of ALPL in stem cells
5) Confidence 0.16 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.07 Pain Relevance 0
The MVs, are enriched in NPP1 and TNAP, whose catalytic domains are predominantly exposed at the external face of MVs.
Gene_expression (exposed) of TNAP in face
6) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.40 Pain Relevance 0
Tissue-nonspecific alkaline phosphatase (TNAP) was also detected in these cells and used as a marker for their undifferentiated stage [35].
Gene_expression (detected) of TNAP
7) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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