INT21569

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.55
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
neurons 2
retinas 1
sciatic nerves 1
spinal cord 1
nociceptors 1
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 6 100.00 Very High Very High Very High
Pain 3 99.74 Very High Very High Very High
Enkephalin 2 99.74 Very High Very High Very High
Opioid 3 99.24 Very High Very High Very High
Inflammation 48 99.08 Very High Very High Very High
antinociception 1 98.96 Very High Very High Very High
ischemia 57 98.88 Very High Very High Very High
Sciatic nerve 6 98.80 Very High Very High Very High
Spinal cord 14 97.88 Very High Very High Very High
Neuritis 8 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 144 99.82 Very High Very High Very High
INFLAMMATION 57 99.08 Very High Very High Very High
Cv Unclassified Under Development 54 98.88 Very High Very High Very High
Reperfusion Injury 18 98.52 Very High Very High Very High
Sepsis 63 98.40 Very High Very High Very High
Stress 83 98.24 Very High Very High Very High
Experimental Autoimmune Neuritis 8 97.84 Very High Very High Very High
Death 70 93.40 High High
Immunization 4 88.24 High High
Breast Cancer 1 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that JNK phosphorylation is closely associated with the clearance of inflammatory cells as well as the activation of Schwann cells in the EAN affected sciatic nerves.
JNK Binding (associated) of in sciatic nerves associated with inflammation, sciatic nerve and neuritis
1) Confidence 0.48 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 1.25 Pain Relevance 0.99
RESULTS: In control rats, activated JNK and c-Jun were primarily associated with mechanoceptors; in diabetes this was increased, but a greater increase was seen in nociceptors.
JNK Binding (associated) of in nociceptors
2) Confidence 0.36 Published 2006 Journal Diabetologia Section Body Doc Link 16456679 Disease Relevance 0 Pain Relevance 0
, apoptosis signal-regulating kinase 1 (ASK1), SAPK/ERK kinase 1 (SEK1) and c-Jun N-terminal kinase (JNK) is associated with the damaged retinal neurons induced by ischemia-reperfusion injury.
JNK Binding (associated) of in neurons associated with reperfusion injury, ischemia and apoptosis
3) Confidence 0.26 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2699777 Disease Relevance 0.69 Pain Relevance 0.13
, ASK1, SEK1/MEK4, and JNK is associated with damaged neurons after ischemia-reperfusion injury in rat retinas.


JNK Binding (associated) of in retinas associated with reperfusion injury and ischemia
4) Confidence 0.26 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.24 Pain Relevance 0.20
, apoptosis signal-regulating kinase 1 (ASK1), SAPK/ERK kinase 1 (SEK1) and c-Jun N-terminal kinase (JNK) is associated with the damaged retinal neurons induced by ischemia-reperfusion injury.
c-Jun N-terminal kinase Binding (associated) of in neurons associated with reperfusion injury, ischemia and apoptosis
5) Confidence 0.26 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2699777 Disease Relevance 0.69 Pain Relevance 0.13
This drug reduces TLR4 activation, in association with downstream JNK and IKK/NF-?
JNK Binding (association) of
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.92 Pain Relevance 0.23
However, situation with JNK is not as clear, especially as in the same setting MP potently inhibited Jun activation.
JNK Spec (clear) Binding (situation) of
7) Confidence 0.10 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.04
Differential interactions of cholecystokinin and FLFQPQRF-NH2 with mu and delta opioid antinociception in the rat spinal cord.
FLFQPQRF-NH2 Binding (interactions) of in spinal cord associated with antinociception, enkephalin, opioid, cholecystokinin and spinal cord
8) Confidence 0.07 Published 1990 Journal Neuropeptides Section Title Doc Link 2177165 Disease Relevance 0 Pain Relevance 1.60
Many (Tran et al. 2001, Bortner & Cidlowski 2002, Ley et al. 2004), but not all (Wang et al. 2000, Zhuang & Schnellmann 2006), such studies have supported the general view that activation of the ERK pathway mediates survival signals which counteract pro-apoptotic effects associated with JNK and p38 activation.
JNK Binding (associated) of associated with apoptosis
9) Confidence 0.05 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.76 Pain Relevance 0.11

General Comments

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