INT2157

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 6.07
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
follicle 4
hypothalamus 2
plasma 2
external jugular veins 2
lever 2
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 35 100.00 Very High Very High Very High
opiate 18 100.00 Very High Very High Very High
narcan 70 99.84 Very High Very High Very High
Raphe 2 99.80 Very High Very High Very High
anesthesia 22 99.76 Very High Very High Very High
Morphine 30 99.74 Very High Very High Very High
Opioid 13 99.56 Very High Very High Very High
antagonist 63 99.40 Very High Very High Very High
Endogenous opioid 9 97.68 Very High Very High Very High
tolerance 7 93.60 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 39 100.00 Very High Very High Very High
Stress 204 99.80 Very High Very High Very High
Galactorrhea 4 99.58 Very High Very High Very High
Hemorrhage 2 99.52 Very High Very High Very High
Urological Neuroanatomy 31 98.88 Very High Very High Very High
Volume Depletion And Dehydration 12 98.48 Very High Very High Very High
Primary Sclerosing Cholangitis 27 96.12 Very High Very High Very High
Polycystic Ovary Syndrome 63 95.64 Very High Very High Very High
Pressure Volume 2 Under Development 5 93.84 High High
Aids-related Complex 7 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two narcotic antagonists, naloxone and naltrexone, significantly elevated serum LH levels in male rats within minutes after their sc injection.
Positive_regulation (elevated) of Gene_expression (levels) of LH associated with antagonist and narcan
1) Confidence 0.69 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.47
The exogenous opioid morphine blocked the increase in LH produced by naloxone in a dose-dependent fashion, suggesting that the specific receptor-blocking effects of the antagonist could account for its enhancement of serum LH levels.
Positive_regulation (increase) of Gene_expression (produced) of LH associated with antagonist, narcan, opioid and morphine
2) Confidence 0.69 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.63
Bilateral lesions of the medial region of the PAG, which did not encroach upon the dorsal raphe nucleus, elevated basal levels of serum LH.
Positive_regulation (elevated) of Gene_expression (levels) of serum LH in PAG associated with urological neuroanatomy and raphe
3) Confidence 0.66 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 7022252 Disease Relevance 0.79 Pain Relevance 1.02
In contrast, naloxone was able to increase LH levels in TP-treated castrated rats even at the highest dose tested (50 mg/kg).
Positive_regulation (increase) of Gene_expression (levels) of LH associated with narcan
4) Confidence 0.50 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.66
In previous studies, it was demonstrated that morphine pellet implantation markedly sensitized adult male rats to the subsequent elevations in serum luteinizing hormone (LH) levels produced by the opiate antagonist, naloxone.
Positive_regulation (elevations) of Gene_expression (produced) of LH associated with antagonist, narcan, opiate and morphine
5) Confidence 0.50 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3528453 Disease Relevance 0.07 Pain Relevance 0.71
Serum LH levels in rats castrated 5 days earlier were significantly reduced by intracerebroventricular administration of homologous (rat) CRF (0.02-2 nmol) within 30 min posttreatment; the effects of 0.02 nmol CRF lasted for at least 2 h, whereas those of 0.2 and 2 nmol CRF were evident for up to 6 h.
Positive_regulation (lasted) of Gene_expression (levels) of Serum LH associated with intracerebroventricular
6) Confidence 0.50 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.39
During inescapable NGC stimulation, rates of lever-pressing for LH trains were greatest when LH pulses preceded NGC pulses again at intervals of 0.1 or 10 ms.
Positive_regulation (lever-pressing) of Gene_expression (lever-pressing) of LH in lever
7) Confidence 0.49 Published 1982 Journal Brain Res. Section Abstract Doc Link 7188027 Disease Relevance 0 Pain Relevance 0.09
Naloxone causes rapid, dose-dependent increases in serum LH levels in the male, apparently by blocking the actions of an endogenously occurring opioid peptide which normally inhibits the release of LH.
Positive_regulation (increases) of Gene_expression (levels) of LH associated with narcan and opioid
8) Confidence 0.46 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7005427 Disease Relevance 0 Pain Relevance 1.02
Hyperprolactinemia was associated with increases in mean serum LH levels during the bleeding period and in the absolute amplitude of LH peaks.
Positive_regulation (increases) of Gene_expression (levels) of LH associated with galactorrhea and hemorrhage
9) Confidence 0.46 Published 1994 Journal Vet Hum Toxicol Section Abstract Doc Link 7900272 Disease Relevance 0.37 Pain Relevance 0.44
The effect of neurotensin (NT) on circulating LH levels following its discrete microinjection into this region was evaluated.
Positive_regulation (circulating) of Gene_expression (levels) of LH
10) Confidence 0.46 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6717745 Disease Relevance 0.25 Pain Relevance 0
Intravenous administrations of morphine (10 mg/kg), but not beta-endorphin (1 mg/kg), to normal female rats resulted in a 2-fold increase in LH concentrations similar to that observed in ovariectomized rats, whereas both treatments similarly increased PRL concentrations.
Positive_regulation (increase) of Gene_expression (concentrations) of LH associated with morphine
11) Confidence 0.46 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2755561 Disease Relevance 0.38 Pain Relevance 0.69
The objectives of the present study were to determine: (1) if this paradoxical effect of morphine on LH secretion could be antagonized by naloxone; (2) whether beta-endorphin also stimulated LH secretion under similar conditions; (3) what influence, if any, the ovaries have on the expression of this opiate-induced LH secretion, and (4) whether this paradoxical effect of morphine extended to prolactin (PRL) secretion.
Spec (whether) Positive_regulation (induced) of Gene_expression (expression) of LH in ovaries associated with narcan, opiate and morphine
12) Confidence 0.43 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2755561 Disease Relevance 0.36 Pain Relevance 0.84
However, despite the bromocriptine-induced suppression of prolactin levels, there was no increase in LH levels which remained low throughout the suckling period.
Neg (no) Positive_regulation (increase) of Gene_expression (levels) of LH
13) Confidence 0.42 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.41
It was found that beta-EP blocked the preovulatory surge of LH release and ovulation, while it did not affect LH release in response to LH-RH injection.
Positive_regulation (response) of Gene_expression (injection) of LH
14) Confidence 0.40 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6319110 Disease Relevance 0.22 Pain Relevance 0.07
In fact, 60 min of progressive submaximal treadmill exercise in the mid-follicular phase produces a small surge-like increase in plasma levels of LH (from ?
Positive_regulation (increase) of Gene_expression (levels) of LH in plasma
15) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.20 Pain Relevance 0.12
257 pmol/L on the morning of proestrus, preceding the zenith of the LH surge (?
Positive_regulation (preceding) of Gene_expression (surge) of LH
16) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.13 Pain Relevance 0
Furthermore, it has been reported that a rapid blood volume depletion from the external jugular veins under constant ether anesthesia is able to increase plasma LH concentrations (from ?
Positive_regulation (increase) of Gene_expression (concentrations) of LH in external jugular veins associated with anesthesia and volume depletion and dehydration
17) Confidence 0.31 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.45 Pain Relevance 0.17
Moreover, it has been reported that a single injection of adrenocorticotropic hormone (ACTH) to estrogen-primed intact and ovariectomized immature rats causes a significant elevation in serum LH and FSH levels.
Positive_regulation (elevation) of Gene_expression (levels) of LH
18) Confidence 0.31 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.24 Pain Relevance 0
Thus naloxone (NAL), a specific opiate antagonist, has been shown to reduce basal serum levels of PRL and GH, and to elevate serum levels of LH and follicle stimulating hormone in male rats.
Positive_regulation (elevate) of Gene_expression (levels) of LH in follicle associated with antagonist, narcan and opiate
19) Confidence 0.28 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247213 Disease Relevance 0.09 Pain Relevance 0.74
The results showed that the levels of T and LH were obviously increased in rats of different ages, and the level of E was also significantly elevated in baby rats.
Positive_regulation (increased) of Gene_expression (levels) of LH
20) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0

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