INT215706

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

endosome (Lamtor1) Golgi apparatus (Lamtor1) cytoplasm (Cdk6) nucleus (Cdk6) plasma membrane (Lamtor1) cell cycle (Cdk6)

Cdk6 (Rattus norvegicus) Lamtor1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 1 8.96 antagonist 18 5.00 Central nervous system 13 5.00 Hippocampus 13 5.00 adenocard 12 5.00 Neurotransmitter 12 5.00 ischemia 9 5.00 Glutamate 9 5.00 agonist 6 5.00 Spinal cord 4 5.00

Disease Link Frequency Relevance Heat Gliosis 1 32.04 Cicatrix 1 19.28 Neurodegenerative Disease 13 5.00 Disease 11 5.00 Cv Unclassified Under Development 8 5.00 Hypoxia 7 5.00 Embryonal Carcinoma 7 5.00 Targeted Disruption 7 5.00 Death 5 5.00 Neuropathic Pain 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Two families of cdk inhibitors regulate the activity of G1-type cyclins-cdks complexes: the Ink4 family (p16, p15, p18, and p19), which blocks the activity of cyclin D-cdk4-6 complexes, and the Cip/Kip family (p21, p27, and p57), which preferentially inhibits cyclin E-cdk2 complexes and also acts as a scaffold for the catalytically active cyclin D-cdk4-6 complexes.

cyclin D-cdk4-6 Binding (complexes) of p18

1) Confidence 0.04 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0

General Comments

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