INT21572

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Context Info
Confidence 0.71
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 2.52
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pebp1) mitochondrion (Pebp1) extracellular space (Pebp1)
aging (Pebp1) Golgi apparatus (Pebp1) response to stress (Pebp1)
Anatomy Link Frequency
bladder 2
bronchiole 1
adrenal gland 1
small intestine 1
salivary gland 1
Pebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 15 100.00 Very High Very High Very High
antinociception 7 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Neuropeptide 4 99.74 Very High Very High Very High
Central nervous system 18 99.72 Very High Very High Very High
opioid receptor 6 97.84 Very High Very High Very High
mu opioid receptor 1 97.80 Very High Very High Very High
Central grey 1 94.80 High High
Opioid 7 93.08 High High
Hippocampus 19 92.60 High High
Disease Link Frequency Relevance Heat
Lower Urinary Tract Symptoms 54 95.44 Very High Very High Very High
Cancer 1 95.04 Very High Very High Very High
Urological Neuroanatomy 1 94.80 High High
Hypoxia 10 93.64 High High
Overactive Bladder 99 92.88 High High
Benign Prostatic Hypertrophy 72 91.04 High High
Learning Disorders 2 85.52 High High
Nervous System Injury 18 84.40 Quite High
Dementia 2 83.92 Quite High
Cv Unclassified Under Development 1 76.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanism of expression of the rat HCNP precursor protein gene.
Gene_expression (expression) of HCNP precursor protein gene associated with neuropeptide
1) Confidence 0.71 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9105667 Disease Relevance 0 Pain Relevance 0.14
These results suggest that HCNP-precursor gene expression is regulated by a general transactivation factor such as SP1, and that the specific presence of the bioactive HCNP in certain tissues results from post-translational events such as proteolytic processing of the precursor protein, which takes place predominantly in the hippocampus of young rats.
Gene_expression (expression) of HCNP-precursor gene in hippocampus associated with hippocampus
2) Confidence 0.71 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9105667 Disease Relevance 0 Pain Relevance 0.12
The HCNP sequences aligned at the N-terminal regions of their precursors.
Gene_expression (aligned) of HCNP
3) Confidence 0.40 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637590 Disease Relevance 0 Pain Relevance 0.16
HCNP has been detected in variety of tissues and organs, such as the salivary gland, bronchiole, adrenal gland, small intestine and testis.
Gene_expression (detected) of HCNP in bronchiole
4) Confidence 0.38 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.11 Pain Relevance 0.10
Of the changes in protein expression detected in this proteomic analysis, the over-expression of OPTN and the under-expression of transgelin and HCNP were most noteworthy (Fig. 5) (Table 1, 2).


Gene_expression (expression) of HCNP
5) Confidence 0.34 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.44 Pain Relevance 0
In addition, four proteins, such as peroxiredoxin 2, transgelin, hippocampal cholinergic neurostimulating peptide (HCNP) and beta-galactoside-binding lectin, were under-expressed in the bladder of BOO group.
Gene_expression (expressed) of HCNP in bladder
6) Confidence 0.30 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2779299 Disease Relevance 0.33 Pain Relevance 0
Four proteins (peroxiredoxin 2, transgelin [SM22 alpha], hippocampal cholinergic neurostimulating peptide [HCNP] and beta-galactoside-binding lectin) were under-expressed in the obstructed bladder.
Gene_expression (expressed) of HCNP in bladder
7) Confidence 0.30 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.34 Pain Relevance 0
In this study, we detected the over-expression of three proteins (OPTN, thioredoxin and preprohaptoglobin), and the under-expression of four proteins (peroxiredoxin 2, transgelin [SM22 alpha], HCNP, and beta-galactoside-binding lectin).
Gene_expression (expression) of HCNP
8) Confidence 0.30 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.31 Pain Relevance 0.08
Together with the finding of the present study, that PEBP is also expressed in HNSC, is concordant with the finding that hippocampal neural stem and progenitor cells have the ability to produce cholinergic neurons [35-37].
Gene_expression (expressed) of PEBP in stem
9) Confidence 0.28 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0.17 Pain Relevance 0.12
We have identified another differentiation-related protein, the Phosphatidyl Ethanolamine-Binding Protein (PEBP) which is highly expressed in the brain but also a major component of epididymal secretions and sperm plasma membranes [31].
Gene_expression (expressed) of PEBP in sperm
10) Confidence 0.28 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0 Pain Relevance 0.12
HCNP has been detected in variety of tissues and organs, such as the salivary gland, bronchiole, adrenal gland, small intestine and testis.
Gene_expression (detected) of HCNP in adrenal gland
11) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.11 Pain Relevance 0.10
HCNP has been detected in variety of tissues and organs, such as the salivary gland, bronchiole, adrenal gland, small intestine and testis.
Gene_expression (detected) of HCNP in small intestine
12) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.11 Pain Relevance 0.10
HCNP has been detected in variety of tissues and organs, such as the salivary gland, bronchiole, adrenal gland, small intestine and testis.
Gene_expression (detected) of HCNP in testis
13) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.11 Pain Relevance 0.10
HCNP has been detected in variety of tissues and organs, such as the salivary gland, bronchiole, adrenal gland, small intestine and testis.
Gene_expression (detected) of HCNP in salivary gland
14) Confidence 0.13 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.11 Pain Relevance 0.10
Some pharmacological properties of newly synthesized derivatives of (-)-6 beta-acetylthionormorphine, AcS-morphine (KT-88), KT-89 and KT-90 and their interactions with opioid receptors were studied. 2.
Gene_expression (synthesized) of AcS-morphine associated with opioid receptor and morphine
15) Confidence 0.07 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 0.82
Although both high and low efficacy agonists produce antinociception, low efficacy agonists such as morphine produce limited MOPr internalization suggesting that MOPr internalization and signaling leading to antinociception are independent.
Gene_expression (produce) of morphine produce associated with antinociception, agonist and morphine
16) Confidence 0.02 Published 2010 Journal Neuroscience Section Abstract Doc Link 20394808 Disease Relevance 0.09 Pain Relevance 0.99
Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution.
Gene_expression (redistribution) of morphine associated with morphine
17) Confidence 0.01 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 15764678 Disease Relevance 0.27 Pain Relevance 0.28

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