INT215722

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
spinal cord neurons 1
hippocampus 1
P2rx4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 98.80 Very High Very High Very High
Pain 4 97.36 Very High Very High Very High
Hippocampus 13 96.12 Very High Very High Very High
adenocard 12 90.92 High High
Glutamate 14 84.68 Quite High
agonist 13 80.80 Quite High
antagonist 22 79.12 Quite High
Inflammation 5 46.96 Quite Low
gABA 4 35.44 Quite Low
allodynia 3 16.72 Low Low
Disease Link Frequency Relevance Heat
Pain 5 97.36 Very High Very High Very High
Convulsion 3 97.36 Very High Very High Very High
Muscle Weakness 1 92.76 High High
Epilepsy 4 84.32 Quite High
Neurological Disease 1 63.84 Quite High
Apoptosis 17 62.08 Quite High
INFLAMMATION 6 46.96 Quite Low
Neurodegenerative Disease 14 45.28 Quite Low
Stress 2 41.48 Quite Low
Nociception 2 21.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In activated microglia, P2X4 is up-regulated and promotes BDNF release in spinal cord neurons contributing to pain signalling [33].
Regulation (regulated) of P2X4 in spinal cord neurons associated with pain and spinal cord
1) Confidence 0.20 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.10 Pain Relevance 0.15
GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139].
Regulation (modulation) of P2X4 in hippocampus associated with convulsion and hippocampus
2) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.79 Pain Relevance 0.46

General Comments

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