INT215732

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
microglia 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
cytokine 3 89.48 High High
Central nervous system 13 86.32 High High
adenocard 12 81.64 Quite High
Neurotransmitter 12 71.64 Quite High
Glutamate 9 68.20 Quite High
gABA 4 67.20 Quite High
ischemia 9 60.92 Quite High
Hippocampus 13 58.28 Quite High
Inflammatory response 1 42.56 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Hypoxia 7 76.64 Quite High
Stress 2 68.24 Quite High
Cv Unclassified Under Development 8 60.92 Quite High
Brain Injury 1 44.04 Quite Low
Necrosis 1 40.64 Quite Low
Cancer 3 40.28 Quite Low
Apoptosis 4 27.28 Quite Low
Neurological Disease 1 24.80 Low Low
Epilepsy 4 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATP selectively suppresses the synthesis of the inflammatory protein microglial response factor through calcium influx via P2X7 receptors in microglia [129], which also leads to enhancement of interferon-?
Negative_regulation (suppresses) of P2X7 Binding (receptors) of in microglia associated with inflammation
1) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.74 Pain Relevance 0.49

General Comments

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