INT215734

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ces1c) endoplasmic reticulum (Ces1c)
Anatomy Link Frequency
epididymis 2
Ces1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 25.76 Quite Low
antagonist 18 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gliosis 1 48.84 Quite Low
Cicatrix 1 36.08 Quite Low
Targeted Disruption 39 5.00 Very Low Very Low Very Low
Sperm Disorder 16 5.00 Very Low Very Low Very Low
Death 13 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 13 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Male Infertility 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HongrES1 expression is androgen-dependent and developmentally regulated
Regulation (regulated) of Gene_expression (expression) of HongrES1
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
The developmental changes of HongrES1 expression at both mRNA and protein levels throughout the life-span of rats were surveyed by northern blot and western blot analysis (Figure 2C, 2D and 2E).
Regulation (changes) of Gene_expression (expression) of HongrES1
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
The relevant proteins include three D-type cyclins (D1, D2, and D3) that, in different combinations, bind to and allosterically regulate one of two cdk subunits, cdk4 and cdk6, as well as the E-type cyclins (E1 and E2), which govern the activity of a single catalytic subunit, cdk2 [176].
Regulation (regulate) of Gene_expression (one) of E1
3) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0
HongrES1 expression is androgen-dependent and developmentally regulated
Regulation (androgen) of Gene_expression (expression) of HongrES1
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
Since the epididymis is an androgen-responsive organ [16], the effects of androgen manipulation on HongrES1 mRNA expression were investigated in the castrated rat by northern blot analysis (Figure 2A).
Spec (investigated) Regulation (effects) of Gene_expression (expression) of HongrES1 mRNA in epididymis
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0

General Comments

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