INT215757

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.84
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
choroid plexus 1
neurons 1
astrocytes 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 18 99.98 Very High Very High Very High
Spinal cord 19 96.64 Very High Very High Very High
intrathecal 20 92.68 High High
antagonist 37 91.92 High High
allodynia 8 91.92 High High
Glutamate 19 91.84 High High
Hippocampus 26 88.72 High High
Neuropathic pain 15 88.32 High High
withdrawal 7 83.12 Quite High
agonist 19 82.44 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 16 99.98 Very High Very High Very High
Death 10 96.60 Very High Very High Very High
Neuropathic Pain 47 91.92 High High
Stress 6 82.20 Quite High
Hypoxia 14 81.68 Quite High
Apoptosis 8 78.16 Quite High
Neurodegenerative Disease 26 63.92 Quite High
Disease 23 56.20 Quite High
Nervous System Injury 19 52.40 Quite High
Amyloid Plaque 4 43.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following induction of ischemia P2X7 receptor mRNA transcription and protein expression were elevated in cultured cerebellar granule neurons and organotypic hippocampal cultures [163].
Transcription (transcription) of P2X7 receptor in neurons associated with ischemia
1) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.14 Pain Relevance 0.42
For instance, in primary cultures of human fetal astrocytes basal levels of P2X7 receptor mRNA transcription and protein expression were detected [62].
Transcription (transcription) of P2X7 receptor in astrocytes
2) Confidence 0.16 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.21 Pain Relevance 0.22
By contrast, the mRNA levels of P2X7 and P2Y12 receptors were not changed.
Transcription (levels) of P2X7
3) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.49 Pain Relevance 0.76
RT-PCR experiments have determined the expression of mRNA for P2X1, P2X2, P2X4, P2X5 P2X6 and P2X7 in choroid plexus [94,95] (Table 1).
Spec (determined) Transcription (expression) of P2X7 in choroid plexus
4) Confidence 0.05 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.04

General Comments

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