INT215787

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
synapses 1
microglia 1
P2rx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 1 92.20 High High
agonist 49 90.56 High High
Hippocampus 2 86.44 High High
excitatory amino acid 11 86.04 High High
Glutamate 86 84.84 Quite High
ischemia 2 84.28 Quite High
Potency 27 82.32 Quite High
Nucleus accumbens 22 78.28 Quite High
medulla 18 63.84 Quite High
Brush evoked pain 1 54.00 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 3 84.28 Quite High
Injury 43 77.44 Quite High
Nervous System Injury 2 76.08 Quite High
Death 2 71.20 Quite High
Neuropathic Pain 1 54.00 Quite High
Stab Wounds 6 21.12 Low Low
INFLAMMATION 7 14.64 Low Low
Apoptosis 17 5.00 Very Low Very Low Very Low
Apnoea 9 5.00 Very Low Very Low Very Low
Dyspnea 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there are few central synapses where fast neurotransmission is predominantly mediated via release of ATP and activation of postsynaptic P2X receptors (Edwards et al. 1992; Khakh & North, 2006; Burnstock, 2007), ATP can be released as a cotransmitter (Jo & Schlichter, 1999; see Pankratov et al. 2006 for review).
Localization (release) of P2X in synapses
1) Confidence 0.68 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.20
The zP2X4 receptor crystal structure shows that the eight conserved residues predicted to contribute to the ATP binding site are indeed in close proximity (Kawate et al., 2009), and this has also been found for a homology model of the P2X1 receptor (Lys68, Lys70, Phe185, Thr 186 from one subunit, and Asn290, Phe291, Arg292 and Lys309 in the adjacent one; P2X1 receptor numbering, Figure 1) and P2X2 receptors (Keceli and Kubo, 2009; Kubo et al., 2009).
Localization (numbering) of P2X1
2) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.12
Confocal microscopic analysis with OX 42 [39] at organotypic cultures showed that P2X4 and P2X7 are expressed on microglia, whereas P2X1 and P2Y1,2,12, although present in the slices, do not colocalize at microglia, and the P2X6 receptor is absent.
Neg (not) Localization (colocalize) of P2X1 in microglia
3) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.49 Pain Relevance 0.22

General Comments

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