INT21579

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 12.41
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
macrophages 2
tendon cells 2
cartilage 2
PGE2 2
monocytes 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 259 100.00 Very High Very High Very High
Osteoarthritis 94 99.84 Very High Very High Very High
dexamethasone 7 99.84 Very High Very High Very High
Infliximab 104 99.82 Very High Very High Very High
methotrexate 11 99.70 Very High Very High Very High
rheumatoid arthritis 222 99.56 Very High Very High Very High
Inflammatory mediators 13 99.36 Very High Very High Very High
Inflammation 270 98.48 Very High Very High Very High
cytokine 158 94.88 High High
endometriosis 99 94.00 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 124 99.84 Very High Very High Very High
Rheumatoid Arthritis 226 99.56 Very High Very High Very High
Cancer 110 99.48 Very High Very High Very High
INFLAMMATION 301 99.36 Very High Very High Very High
Endometriosis 126 98.24 Very High Very High Very High
Injury 53 98.24 Very High Very High Very High
Apoptosis 31 98.16 Very High Very High Very High
Necrosis 17 97.80 Very High Very High Very High
Stress 63 97.64 Very High Very High Very High
Infection 19 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone, colchicine or retinoic acid all inhibited collagenase synthesis by monocytes in a dose-dependent manner although the effect of these drugs on monocyte PGE2 synthesis differed.
Negative_regulation (inhibited) of Gene_expression (synthesis) of collagenase in monocytes associated with dexamethasone
1) Confidence 0.57 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.17 Pain Relevance 0.32
Inhibition of collagenase synthesis by dexamethasone, but not colchicine or retinoic acid, could be reversed by PGE2 or phospholipase A2.
Negative_regulation (Inhibition) of Gene_expression (synthesis) of collagenase associated with dexamethasone
2) Confidence 0.57 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.15 Pain Relevance 0.37
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Negative_regulation (inhibitor) of Gene_expression (membrane) of TIMP associated with metalloproteinase
3) Confidence 0.41 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.65 Pain Relevance 0.19
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of Gene_expression (levels) of TIMP1 associated with methotrexate
4) Confidence 0.37 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.54 Pain Relevance 0.22
Collagenase production was also unaffected by etodolac (60 micrograms/ml).
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (production) of Collagenase
5) Confidence 0.36 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2545406 Disease Relevance 0.17 Pain Relevance 0.12
Furthermore, flurbiprofen was shown to induce the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9.
Negative_regulation (inhibitor) of Gene_expression (expression) of TIMP-1 associated with metalloproteinase
6) Confidence 0.36 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.34 Pain Relevance 0.29
Furthermore, flurbiprofen was shown to induce the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9.
Negative_regulation (inhibitor) of Gene_expression (expression) of metalloproteinase-1 associated with metalloproteinase
7) Confidence 0.31 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.34 Pain Relevance 0.29
These results indicate that the documented favourable clinical response may in part be due to in vivo inhibition of classic neutrophil and mesenchymal collagenase/MMP-8 activities produced by doxycycline.
Negative_regulation (inhibition) of Gene_expression (produced) of collagenase in neutrophil
8) Confidence 0.29 Published 1998 Journal Rheumatol. Int. Section Abstract Doc Link 9542777 Disease Relevance 0.41 Pain Relevance 0.50
In our study celecoxib was able to neutralize the inductive potential of the tumor cell microenvironment by decreasing levels of MMPs, TIMP1, TIMP2, and laminin (Figures 4 and 5).
Negative_regulation (decreasing) of Gene_expression (levels) of TIMP1 associated with cancer and metalloproteinase
9) Confidence 0.26 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.46 Pain Relevance 0.14
Recent findings showed that the expression of MMP and tissue inhibitor of metalloproteinase (TIMP) in tendon cells were sensitive to mechanical overload or stress-deprivation [131,154].
Negative_regulation (inhibitor) of Gene_expression (expression) of TIMP in tendon cells associated with stress and metalloproteinase
10) Confidence 0.25 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 1.62 Pain Relevance 0.43
CN-100 did not inhibited directly the collagenase production, but significantly prevent the biosynthesis of PGE2 known as an inflammatory mediator.
Negative_regulation (inhibited) of Gene_expression (production) of collagenase in PGE2 associated with inflammation
11) Confidence 0.24 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2177561 Disease Relevance 0.25 Pain Relevance 0.20
g/mL) of PHT and HPPH, on the other hand, significantly reduced TIMP-1 levels.
Negative_regulation (reduced) of Gene_expression (levels) of TIMP-1
12) Confidence 0.21 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.20 Pain Relevance 0.04
In this study, elevated levels of PHT in LPS-stimulated macrophages were associated with decreases in both MMP and TIMP levels.
Negative_regulation (decreases) of Gene_expression (levels) of TIMP in macrophages
13) Confidence 0.21 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.07 Pain Relevance 0
Assay of collagenase activity
Negative_regulation (Assay) of Gene_expression (activity) of collagenase
14) Confidence 0.18 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 0 Pain Relevance 0.04
[169], may indirectly cause a selective decrease in collagenase production in the synovial tissue.
Negative_regulation (decrease) of Gene_expression (production) of collagenase
15) Confidence 0.17 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.47 Pain Relevance 0.42
In this process, screening of natural products from marine organisms that could potentially inhibit the expression of metalloproteinases has gained a huge popularity, which became a hot field of research in life sciences.
Negative_regulation (inhibit) of Gene_expression (expression) of metalloproteinases associated with metalloproteinase
16) Confidence 0.15 Published 2010 Journal Biochemistry Research International Section Abstract Doc Link PMC3004377 Disease Relevance 0.13 Pain Relevance 0.29
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Negative_regulation (downregulates) of Gene_expression (expression) of TIMP in synovium associated with infliximab and metalloproteinase
17) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.19 Pain Relevance 0.54
Although TIMP-1 is highly expressed in cartilage and reduced in OA, we failed to detect any effect of leptin on its expression (data not shown).
Negative_regulation (reduced) of Gene_expression (expressed) of TIMP-1 in cartilage associated with osteoarthritis
18) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.70 Pain Relevance 0.21
It has been reported that the RA synovial endothelium produces decreased amounts of TIMP [131].
Negative_regulation (decreased) of Gene_expression (produces) of TIMP in endothelium associated with rheumatoid arthritis
19) Confidence 0.11 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.92 Pain Relevance 0.49
g/mL), through down-regulation of intracellular matrix metalloproteinases (MMP-2) expression on endothelial cells. [30].
Negative_regulation (down-regulation) of Gene_expression (expression) of metalloproteinases in endothelial cells associated with metalloproteinase
20) Confidence 0.09 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.28 Pain Relevance 0.09

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