INT215809

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 0.53
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnma1) endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
transmembrane transport (Kcnma1)
Anatomy Link Frequency
plasma 1
Section 3 1
Kcnma1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 96 100.00 Very High Very High Very High
Neuronal excitability 1 90.96 High High
imagery 16 88.96 High High
Neurotransmitter 2 77.60 Quite High
Central nervous system 8 55.76 Quite High
ischemia 45 44.48 Quite Low
Glutamate receptor 6 39.80 Quite Low
excitatory amino acid 1 36.56 Quite Low
agonist 9 24.24 Low Low
isoflurane 1 15.60 Low Low
Disease Link Frequency Relevance Heat
Stress 28 80.40 Quite High
Reperfusion Injury 30 79.84 Quite High
Epilepsy 2 79.68 Quite High
Miosis 1 78.24 Quite High
Apoptosis 24 53.64 Quite High
Stroke 11 52.40 Quite High
Cv Unclassified Under Development 103 50.56 Quite High
Brain Hemorrhage 9 50.00 Quite Low
Death 28 47.08 Quite Low
Pressure And Volume Under Development 15 42.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BKCa are expressed in amphibian choroid plexus (see Section 3.1), however, there is no evidence for the expression of these channels in mammalian tissue.
Gene_expression (expressed) of BKCa in Section 3
1) Confidence 0.58 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.03
Although we cannot fully explain the differences between the results from the two studies, one possible source of this discrepancy is the fact that the HEK293-cell study relied on the use of heterologous over-expression of both the maxi-K channel proteins and cav-1 (in caveolin-negative HEK293 cells) [8].
Gene_expression (expression) of maxi-K channel
2) Confidence 0.30 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.08 Pain Relevance 0
Various mechanisms contribute to the modulation of maxi-K current expression in MSMCs.
Gene_expression (expression) of maxi-K
3) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0.04
The maxi-K channel contains one caveolin-binding motif in its C-terminus (1007YNMLCFGIY1015) (Fig. 2).
Gene_expression (contains) of maxi-K channel
4) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
To establish whether interactions between maxi-K channels and caveolin affect the endogenous myometrial total outward K+ current, we used a siRNA to inhibit cav-1 gene expression in hMSMCs.
Gene_expression (channels) of maxi-K
5) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
The fact that the current is not abolished demonstrates that maxi-K channels are not solely modulated by cav-1.


Gene_expression (channels) of maxi-K
6) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Interestingly, all three of the mutants used in this study reproduced the inhibitory effects of cav-1 deficiency on maxi-K channel current in hMSMCs, although only in the case of mutant Y1007A, F1012A, Y1015A was the maxi-K-caveolin complex disrupted.
Gene_expression (complex) of maxi-K-caveolin
7) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.05 Pain Relevance 0
Western blot analysis of lipid raft fractions using a maxi-K channel antibody confirmed that WT maxi-K channels were present in fractions that also harbored cav-1 (Fig. 4A, boxed region).
Gene_expression (channels) of maxi-K
8) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
All SLO and OCT images in this work were recorded using this setup.
Gene_expression (images) of SLO
9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.08 Pain Relevance 0.11
Furthermore, some BK channels are rather resistant to iberiotoxin [23] and paxilline may not be entirely BK channel-selective [14].
Gene_expression (resistant) of BK channel
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012709 Disease Relevance 0.19 Pain Relevance 0.16
One problem with these data is that, as noted above, it is well established that isolated mitochondria are contaminated with plasma membrane and thus it is possible that the immunological and patch clamping data were actually detecting the sarcolemmal KCa.


Gene_expression (detecting) of KCa in plasma associated with potassium channel
11) Confidence 0.01 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.13 Pain Relevance 0.32

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