INT215810

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
plasma membrane (Orai1) response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
pore 2
Ca2 (Rattus norvegicus)
Orai1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 8 54.48 Quite High
agonist 7 40.16 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 8 55.04 Quite High
Disease 1 20.80 Low Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 1 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutagenesis of residues within Orai1, predicted to be important for Ca2+ binding within the pore of the channel, also markedly attenuated SOCE and ICRAC [27].
Positive_regulation (important) of Ca2 Binding (binding) of Orai1 in pore
1) Confidence 0.01 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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