INT215810

Context Info Confidence 0.01 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.03

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2) plasma membrane (Orai1) response to stress (Ca2) cytoplasm (Ca2)

Anatomy Link Frequency pore 2 Ca2 (Rattus norvegicus) Orai1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat fibrosis 8 54.48 agonist 7 40.16 Central nervous system 8 5.00 TRP channel 6 5.00 adenocard 3 5.00 Glutamate receptor 3 5.00 Serotonin 3 5.00 potassium channel 2 5.00 addiction 2 5.00 Kinase C 2 5.00

Disease Link Frequency Relevance Heat Cystic Fibrosis 8 55.04 Disease 1 20.80 Pressure And Volume Under Development 4 5.00 Targeted Disruption 4 5.00 Stress 2 5.00 Pain 1 5.00 Disorders Of The Lacrimal System 1 5.00 Age-related Macular Degeneration 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mutagenesis of residues within Orai1, predicted to be important for Ca2+ binding within the pore of the channel, also markedly attenuated SOCE and ICRAC [27].

Positive_regulation (important) of Ca2 Binding (binding) of Orai1 in pore

1) Confidence 0.01 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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