INT21582

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Context Info
Confidence 0.61
First Reported 1987
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 12.39
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
fibroblasts 7
macrophage 2
tendon 2
bladder 2
P-1 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 331 100.00 Very High Very High Very High
Inflammatory mediators 8 100.00 Very High Very High Very High
fibrosis 299 99.80 Very High Very High Very High
cytokine 81 99.78 Very High Very High Very High
rheumatoid arthritis 84 99.16 Very High Very High Very High
Pain 28 98.78 Very High Very High Very High
Inflammation 117 98.00 Very High Very High Very High
cINOD 17 95.68 Very High Very High Very High
dexamethasone 3 94.12 High High
Inflammatory response 10 92.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 140 100.00 Very High Very High Very High
Fibrosis 67 99.80 Very High Very High Very High
Rheumatoid Arthritis 89 99.16 Very High Very High Very High
Rupture 17 99.02 Very High Very High Very High
Cancer 187 98.88 Very High Very High Very High
Pain 26 98.78 Very High Very High Very High
Skin Cancer 14 98.72 Very High Very High Very High
Pulmonary Fibrosis 258 98.56 Very High Very High Very High
Transitional Cell Carcinoma 52 97.88 Very High Very High Very High
Necrosis 12 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, commonly used non-steroidal anti-inflammatory drugs (indomethacin, acetyl salicylic acid and ibuprofen), at doses which block prostaglandin synthesis in cultured fibroblasts, failed to counteract IL-1-induced collagenase and stromelysin gene expression, nor did they affect TIMP expression.
Neg (nor) Regulation (affect) of Gene_expression (expression) of TIMP in fibroblasts associated with inflammation and cinod
1) Confidence 0.61 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.16 Pain Relevance 0.27
These findings provide insight into the intracellular events regulating monocyte collagenase synthesis and also implicate monocytes as a target of anti-inflammatory agents which ameliorate connective tissue degradation associated with chronic inflammatory lesions.
Regulation (regulating) of Gene_expression (synthesis) of collagenase in connective tissue associated with inflammation
2) Confidence 0.60 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.34 Pain Relevance 0.37
The value of MMPs and TIMPs expression in bladder tissue
Regulation (value) of Gene_expression (expression) of TIMP in bladder associated with metalloproteinase
3) Confidence 0.60 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.66 Pain Relevance 0.14
We demonstrated that osteopontin affected fibroblast and epithelial cell proliferation and migration, and that it had fibrosis-relevant effects on MMP and TIMP expressions.
Regulation (effects) of Gene_expression (expressions) of TIMP in fibroblast associated with fibrosis
4) Confidence 0.50 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.90 Pain Relevance 0.33
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Neg (little) Regulation (effect) of Gene_expression (expression) of TIMP in PGE2
5) Confidence 0.45 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.28
Considering the effect of histological grading on the MMP and TIMP levels, only MMP1 differed between grade 1 and 2 (median 4.4 vs. 1.9, p = 0.006) while the concentrations of all parameters were independent of the histolological grade (p = 0.101 – 0.532).
Regulation (effect) of Gene_expression (levels) of TIMP
6) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.59 Pain Relevance 0.06
Collagenase production was also unaffected by etodolac (60 micrograms/ml).
Neg (unaffected) Regulation (unaffected) of Gene_expression (production) of Collagenase
7) Confidence 0.38 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2545406 Disease Relevance 0.17 Pain Relevance 0.12
Recent evidence suggests that profound changes in MMP and TIMP expression and localization take place in the IPF lung microenvironment [44,45,46].
Regulation (changes) of Gene_expression (expression) of TIMP in lung associated with fibrosis
8) Confidence 0.26 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.52 Pain Relevance 0.24
OBJECTIVE: To determine whether changes in the expression of matrix metalloproteinases will bring about tissue remodelling that contributes to the progressive nature and pathology of these diseases of the intervertebral disc.
Spec (whether) Regulation (changes) of Gene_expression (expression) of metalloproteinases in intervertebral disc
9) Confidence 0.26 Published 1997 Journal Spine Section Body Doc Link 9431623 Disease Relevance 0.19 Pain Relevance 0
As tissue homeostasis requires the proper balance of metabolism and catabolism, it is possible that macrophage-derived cytokines, MMPs and TIMP levels are altered in response to PHT and HPPH.
Regulation (altered) of Gene_expression (levels) of TIMP in macrophage associated with cytokine
10) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.69 Pain Relevance 0.29
Thus, the concentrations used in our study represent therapeutic as well as elevated levels of PHT permitting the evaluation of dose on MMP and TIMP production.
Regulation (evaluation) of Gene_expression (production) of TIMP
11) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.09 Pain Relevance 0
The effect of CN-100 on the interleukin 1-induced biosynthesis of prostaglandin E2 (PGE2) and tissue collagenase in rabbit and human rheumatoid synovial fibroblasts was also examined.
Spec (examined) Regulation (effect) of Gene_expression (biosynthesis) of collagenase in fibroblasts
12) Confidence 0.22 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2177561 Disease Relevance 0.24 Pain Relevance 0.19
The effects on TIMP-1 and MMP-1 expression appeared to be mostly dependent on CD44, while the effect on MMP-7 expression was dependent on CD44 and integrin signaling.
Regulation (effects) of Gene_expression (expression) of TIMP
13) Confidence 0.22 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.34 Pain Relevance 0.17
We demonstrated that osteopontin affected fibroblast and epithelial cell proliferation and migration, and that it had fibrosis-relevant effects on MMP and TIMP expressions.
Regulation (effects) of in epithelial cell Gene_expression (expressions) of TIMP in fibroblast associated with fibrosis
14) Confidence 0.17 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.90 Pain Relevance 0.33
On the other hand, numerous studies showed that repetitive mechanical stimulation can affect production of pro-inflammatory mediators [117,118,120-123,130], metalloproteinases [123,131] and matrix syntheses [119] in cultured tendon fibroblasts; while non-tenogenic differentiation of tendon derived stem cells can also be triggered by mechanical stretching [132].
Regulation (affect) of Gene_expression (production) of metalloproteinases in tendon fibroblasts associated with inflammatory mediators and metalloproteinase
15) Confidence 0.14 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 1.01 Pain Relevance 0.21
The utilisation of ALA and linoleic acid (LA) for synthesizing EPA and arachidonic acid (AA) depends on feed concentrations of ALA and LA as well as on other factors.
Regulation (depends) of Gene_expression (synthesizing) of EPA
16) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2875212 Disease Relevance 0.14 Pain Relevance 0.03
Wang et al. isolated the sulfated S. maindroni ink polysaccharide (SIP-SII) from cuttlefish Sepiella maindroni, and examined the effects of SIP-SII on the expression of matrix metalloproteinases MMP-2 and MMP-9 as well as tumor cell invasion and migration.
Spec (examined) Regulation (effects) of Gene_expression (expression) of metalloproteinases associated with cancer and metalloproteinase
17) Confidence 0.09 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.30 Pain Relevance 0.10
g/mL), through down-regulation of intracellular matrix metalloproteinases (MMP-2) expression on endothelial cells. [30].
Regulation (regulation) of Gene_expression (expression) of metalloproteinases in endothelial cells associated with metalloproteinase
18) Confidence 0.09 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.28 Pain Relevance 0.09
Changes in cadherins, gap junctions and matrix metalloproteinases expression have emerged as key factors in melanoma progression.
Regulation (Changes) of Gene_expression (expression) of metalloproteinases associated with metalloproteinase and skin cancer
19) Confidence 0.08 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.15 Pain Relevance 0.11
-estradiol plus relaxin modulated any changes in TIMP-1 expression in the disc explants.


Regulation (changes) of Gene_expression (expression) of TIMP-1
20) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064880 Disease Relevance 0 Pain Relevance 0.13

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