INT215830

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Stim1) plasma membrane (Stim1) cytoskeleton (Stim1)
cytoplasm (Stim1)
Anatomy Link Frequency
neuronal 1
Stim1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 3 93.84 High High
TRP channel 135 84.04 Quite High
agonist 17 44.60 Quite Low
fibrosis 16 43.68 Quite Low
Central nervous system 16 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
Serotonin 6 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 16 44.24 Quite Low
Targeted Disruption 29 37.52 Quite Low
Disease 2 10.00 Low Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disorders Of The Lacrimal System 2 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of STIM1 and Orai1-3 was up-regulated 2.5, 1.8, 1.7, and 1.5 folds in differentiated cells, respectively.
Gene_expression (expression) of STIM1
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.04
Meanwhile, the expression of STIM1 and Orai1-3 was not significantly up-regulated in the differentiated neuronal cells compared to A2B5+ NPCs (Table S3).
Gene_expression (expression) of STIM1 in neuronal
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.07
Thus, we examined the expression change of STIM1 and Orais 1–3 between proliferating A2B5+ NPCs and differentiated cells, and whether knockdown of STIM1 and Orai1 causes a change in the differentiation potency of A2B5+ NPCs in differentiation condition.
Spec (examined) Gene_expression (expression) of STIM1 associated with potency
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.30
Interference RNA knockdown (siRNA) of either STIM1 or Orai1 significantly reduces SOCE and ICRAC [24,26], whereas co-expression of both STIM1 and Orai1 massively increases SOCE and ICRAC [29,30].
Gene_expression (expression) of STIM1
4) Confidence 0.15 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0
Interference RNA knockdown (siRNA) of either STIM1 or Orai1 significantly reduces SOCE and ICRAC [24,26], whereas co-expression of both STIM1 and Orai1 massively increases SOCE and ICRAC [29,30].
Gene_expression (-) of STIM1
5) Confidence 0.15 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0

General Comments

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