INT215839

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.12
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurog3) nucleus (Neurog3) DNA binding (Neurog3)
cytoplasm (Neurog3)
Anatomy Link Frequency
liver 3
epithelial cells 2
pancreas 1
lobe 1
Neurog3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 118 89.88 High High
tolerance 15 70.08 Quite High
Inflammatory response 12 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 151 99.60 Very High Very High Very High
Injury 30 99.00 Very High Very High Very High
Fibrosarcoma 2 99.00 Very High Very High Very High
Frailty 22 98.76 Very High Very High Very High
Hyperglycemia 70 97.84 Very High Very High Very High
Congenital Anomalies 3 86.80 High High
Death 52 82.40 Quite High
Targeted Disruption 59 78.40 Quite High
Obesity 22 74.32 Quite High
Polyploidy 8 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, Ngn3 expression was only observed in ductules within the regenerating portion of the splenic lobe but not within differentiated pancreas tissue.
Gene_expression (expression) of Ngn3 in lobe
1) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.11 Pain Relevance 0
STZ-treatment) or NGN3 overexpression [6], [7], [12], [21].
Gene_expression (overexpression) of NGN3
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.24 Pain Relevance 0.14
-cell development, both with regard to reexpression of Ngn3 and initial FoxM1-independent proliferation.
Gene_expression (reexpression) of Ngn3
3) Confidence 0.54 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.27 Pain Relevance 0
These findings were supported by observation of Ngn3, a marker of endocrine progenitor cells (29), in ductal epithelial cells in both control (Fig. 7G) and FoxM1?
Gene_expression (observation) of Ngn3 in epithelial cells
4) Confidence 0.54 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0 Pain Relevance 0
Recently, it was reported [12] that adenoviral vector-mediated expression of transcription factor Neurogenin3 (NGN3) in liver resulted in a sustain expression of insulin in neo- islets cells derived most likely from the hepatic progenitor oval cells that secrete insulin in a glucose-responsive manner, stably reversing the hyperglycemia.
Gene_expression (expression) of NGN3 in liver associated with hyperglycemia
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.62 Pain Relevance 0
No difference in the number of Ngn3+ ductal epithelial cells was detected between control and FoxM1?
Gene_expression (epithelial cells) of Ngn3 in epithelial cells
6) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.21 Pain Relevance 0.03
Recently, it was reported [12] that adenoviral vector-mediated expression of transcription factor Neurogenin3 (NGN3) in liver resulted in a sustain expression of insulin in neo- islets cells derived most likely from the hepatic progenitor oval cells that secrete insulin in a glucose-responsive manner, stably reversing the hyperglycemia.
Gene_expression (expression) of factor Neurogenin3 in liver associated with hyperglycemia
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827564 Disease Relevance 0.62 Pain Relevance 0
Furthermore, tissue-specific Perk ablation in the entire pancreas (pcPKO, using Pdx1-Cre) causes both diabetes and exocrine atrophy; by contrast, mice with gene deletion only in islets (enPKO, using Ngn3-Cre) exhibit diabetes without exocrine atrophy [11].
Gene_expression (using) of Ngn3-Cre in pancreas associated with diabetes mellitus and frailty
8) Confidence 0.27 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.16 Pain Relevance 0.04
An exciting report demonstrated that expressing a specific combination of three transcription factors, Pdx-1, Ngn3, and musculoaponeurotic fibrosarcoma oncogene homolog A (MafA), resulted in amelioration of hyperglycemia.
Gene_expression (expressing) of Ngn3 associated with hyperglycemia and fibrosarcoma
9) Confidence 0.25 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.49 Pain Relevance 0
Systemic delivery of Pdx-1 carrying the VP16 transcriptional activation domain (Pdx-1/VP16) or Ngn-3 and BTC gene resulted in insulin production in liver [36,37].
Gene_expression (carrying) of Ngn-3 in liver
10) Confidence 0.21 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.39 Pain Relevance 0

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