INT215844

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 9.24
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 3
pancreas 2
macrophages 1
P19 1
exocrine pancreas 1
Ex (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 96 99.36 Very High Very High Very High
Parenteral administration 8 94.72 High High
Inflammation 48 89.44 High High
agonist 16 85.92 High High
midbrain 8 76.72 Quite High
imagery 16 41.92 Quite Low
adenocard 4 28.96 Quite Low
tolerance 12 5.52 Low Low
Chronic pancreatitis 16 5.00 Very Low Very Low Very Low
Bioavailability 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 176 99.16 Very High Very High Very High
INFLAMMATION 144 99.00 Very High Very High Very High
Apoptosis 320 98.96 Very High Very High Very High
Body Weight 56 98.28 Very High Very High Very High
Stress 288 98.24 Very High Very High Very High
Death 424 97.24 Very High Very High Very High
Targeted Disruption 204 97.12 Very High Very High Very High
Congenital Anomalies 52 97.08 Very High Very High Very High
Overnutrition 52 96.48 Very High Very High Very High
Diabetes Mellitus 396 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effect of conditional expression of Spry1 in Wnt1-Cre expressing cells on cranial nerve morphogenesis, E10.5 Spry1;Wnt1-Cre embryos were immunostained with a neurofilament-M antibody.
Gene_expression (embryos) of E10 in embryos
1) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.09 Pain Relevance 0.04
Whole mount in situ hybridization of E10.5 Spry1;Wnt1-Cre embryos show that domains of expression of Dlx5 in the first and second branchial arches are greatly reduced.
Gene_expression (embryos) of E10 in branchial arches
2) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.23 Pain Relevance 0
We examined the expression Spry1 in mouse embryos from E8.0 to E10.0 using whole-mount in situ hybridization.
Spec (examined) Gene_expression (expression) of E10 in embryos
3) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.35 Pain Relevance 0.04
-gal staining (Figure 4A-D) and sections (Figure 4E-H) through E10.5 Spry1;R26R;Wnt1-Cre embryos revealed ?
Gene_expression (staining) of E10 in embryos
4) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.18 Pain Relevance 0
Affymetrix Microarray Suite 5.1 was used to calculate a difference in gene expression between exPKO and wild-type at P19 and P32.
Gene_expression (expression) of exPKO in P19
5) Confidence 0.16 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.06 Pain Relevance 0
Large numbers of infiltrating macrophages and neutrophils were detected in the exPKO pancreas by both acid phosphatase staining (Figure 6E, F), and by TEM (Figure 5D).
Gene_expression (pancreas) of exPKO in macrophages
6) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.50 Pain Relevance 0.12
The exPKO exocrine pancreas exhibits normal protein synthesis and secretion without any indication of ER-stress
Gene_expression (synthesis) of exPKO in exocrine pancreas associated with stress
7) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.68 Pain Relevance 0.13
In contrast in exPKO acinar cells, a high frequency of TUNEL positive cells were observed to have diffuse staining throughout both the nucleus and cytoplasm (Figure 6A, B), consistent with the loss of nuclear membrane integrity.
Gene_expression (acinar cells) of exPKO in nucleus
8) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.92 Pain Relevance 0
As expected, the efficiency of CRE-mediated deletion of Perk was substantially lower than what was observed in the exPKO pancreas and consequently significantly fewer acinar cells succumbed to cell death.
Gene_expression (pancreas) of exPKO in pancreas associated with death
9) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.48 Pain Relevance 0
ExPKO acinar cells die through oncosis, not apoptosis
Gene_expression (acinar cells) of ExPKO in acinar cells associated with apoptosis
10) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.18 Pain Relevance 0
In addition, the frequency of these cells in the exPKO pancreas did not increase as atrophy progressed (Figure 5C).
Gene_expression (pancreas) of exPKO in pancreas associated with frailty
11) Confidence 0.15 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.39 Pain Relevance 0
Pharmacodynamics of EX:
Gene_expression (Pharmacodynamics) of EX
12) Confidence 0.14 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.42 Pain Relevance 0.04
While EX therapy was associated with notable reductions in body weight and pp glucose excursions, insulin glargine caused significantly greater decrease in fasting serum glucose[46].
Gene_expression (therapy) of EX in body associated with body weight
13) Confidence 0.14 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.55 Pain Relevance 0
Long-acting EX:
Gene_expression (acting) of EX
14) Confidence 0.14 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.37 Pain Relevance 0.05
Such investigation results suggest that insulin glargine and EX produce similar benefits as far as HbA(1)c levels are concerned, but EX has added advantage of weight loss.
Gene_expression (produce) of EX associated with overnutrition
15) Confidence 0.13 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 1.32 Pain Relevance 0
Large numbers of infiltrating macrophages and neutrophils were detected in the exPKO pancreas by both acid phosphatase staining (Figure 6E, F), and by TEM (Figure 5D).
Gene_expression (pancreas) of exPKO in neutrophils
16) Confidence 0.05 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.50 Pain Relevance 0.12

General Comments

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