INT215850

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.15
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
retina 2
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 5 78.44 Quite High
nMDA receptor antagonist 10 77.72 Quite High
ischemia 25 77.16 Quite High
Inflammation 122 75.84 Quite High
Inflammatory response 16 69.24 Quite High
cytokine 33 5.00 Very Low Very Low Very Low
anesthesia 15 5.00 Very Low Very Low Very Low
isoflurane 15 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
nMDA receptor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 324 100.00 Very High Very High Very High
Apoptosis 92 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 15 99.06 Very High Very High Very High
Injury 16 98.64 Very High Very High Very High
B-cell Lymphoma 1 98.00 Very High Very High Very High
Death 207 97.20 Very High Very High Very High
Ganglion Cysts 120 94.08 High High
Parkinson's Disease 10 91.88 High High
Colon Cancer 8 85.32 High High
Cancer 144 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further clarify the participation of ER stress, we examined the changes in BiP and CHOP in the retina after NMDA-induced injury.
Spec (examined) Regulation (changes) of CHOP in retina associated with stress and injury
1) Confidence 0.50 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.16 Pain Relevance 0.07
Collectively, the above results indicate that NMDA can cause ER stress in the retina, and that the neurotoxicity induced by NMDA is due in part to a mechanism dependent on CHOP protein induction through excessive ER stress.
Regulation (dependent) of CHOP in retina associated with stress and drug induced neurotoxicity
2) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.06 Pain Relevance 0.04
(active form) may remain to translate BiP and CHOP mRNAs to proteins.
Regulation (translate) of CHOP
3) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.96 Pain Relevance 0
Consequently, ATF4 and CHOP have been considered to be prime targets of PERK-mediated regulation in vivo [7].
Regulation (regulation) of CHOP
4) Confidence 0.24 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.29 Pain Relevance 0.07
Since CHOP is a member of the CCAAT/enhancer-binding protein family that is induced by ER stress and participates in ER-mediated apoptosis, CHOP may be a key molecule in retinal cell death [17].
Regulation (participates) of CHOP associated with stress, apoptosis and death
5) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.02 Pain Relevance 0
Next, we investigated the distribution and time-course of changes in GRP78/BiP and CHOP, a proapoptosis protein, after NMDA injection.
Spec (investigated) Regulation (changes) of CHOP
6) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.49 Pain Relevance 0
The mRNA of the transcription factor CHOP, which is involved in cell division and apoptosis in response to stress, is regulated by ARE [187].
Regulation (regulated) of CHOP associated with stress and apoptosis
7) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.18 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox