INT215854

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.42
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hexb) carbohydrate metabolic process (Hexb) lysosome (Hexb)
Anatomy Link Frequency
macrophages 3
neutrophils 1
Hexb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 24 97.36 Very High Very High Very High
Chronic pancreatitis 4 90.52 High High
Inflammation 12 66.96 Quite High
tolerance 2 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 97.00 Very High Very High Very High
Death 104 92.76 High High
Pancreatitis 44 90.52 High High
Stress 72 50.96 Quite High
Apoptosis 56 5.00 Very Low Very Low Very Low
Frailty 44 5.00 Very Low Very Low Very Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Diabetes Mellitus 18 5.00 Very Low Very Low Very Low
Necrosis 12 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant samples showed a significant increase in genes predominately expressed in infiltrating macrophages and neutrophils such as Mac-2 (a macrophage marker), Mmp12 (macrophage elastase), lysosomal proteins (Lip1 and Hexb), and Lcn2 (neutrophil gelatinase-associated lipocalin precursor) (see Additional file 1; also see Figure 2A for Mac-2).
Positive_regulation (increase) of Gene_expression (expressed) of Hexb in macrophages
1) Confidence 0.34 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.21 Pain Relevance 0.26
Mutant samples showed a significant increase in genes predominately expressed in infiltrating macrophages and neutrophils such as Mac-2 (a macrophage marker), Mmp12 (macrophage elastase), lysosomal proteins (Lip1 and Hexb), and Lcn2 (neutrophil gelatinase-associated lipocalin precursor) (see Additional file 1; also see Figure 2A for Mac-2).
Positive_regulation (increase) of in neutrophils Gene_expression (expressed) of Hexb in macrophages
2) Confidence 0.12 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.21 Pain Relevance 0.26

General Comments

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