INT215880

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) lyase activity (Car2) endoplasmic reticulum (Hspa5)
response to stress (Hspa5) cytoplasm (Car2) cytosol (Car2)
Car2 (Mus musculus)
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 79.16 Quite High
Inflammatory response 12 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 6 81.28 Quite High
INFLAMMATION 18 79.16 Quite High
Pancreatitis 22 78.64 Quite High
Death 52 76.88 Quite High
Disease 1 70.68 Quite High
Apoptosis 28 40.32 Quite Low
Stress 36 39.60 Quite Low
Frailty 22 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PERK's activity is dynamically regulated by association/disassociation of the ER chaperone protein BiP/GRP78, whose activity is regulated by Ca2+ as a cofactor and by ATP as a substrate.
Ca2 Regulation (regulated) of BiP
1) Confidence 0.09 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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