INT215897

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.68
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mcam) plasma membrane (Mcam)
Anatomy Link Frequency
endothelial cells 5
endothelia 1
SHED 1
hematopoietic cells 1
Mcam (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 240 99.84 Very High Very High Very High
Inflammation 41 74.48 Quite High
Central nervous system 60 59.16 Quite High
dexamethasone 3 58.32 Quite High
Inflammatory response 11 53.76 Quite High
anesthesia 21 13.40 Low Low
Multiple sclerosis 18 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 15 100.00 Very High Very High Very High
Skin Cancer 2 100.00 Very High Very High Very High
Disease 302 99.56 Very High Very High Very High
Motor Neuron Diseases 216 96.12 Very High Very High Very High
Systemic Lupus Erythematosus 96 95.28 Very High Very High Very High
Immune System Diseases 12 81.92 Quite High
Nerve Degeneration 36 80.48 Quite High
INFLAMMATION 53 74.48 Quite High
Pathologic Processes 6 71.44 Quite High
Stroke 12 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another of our findings was that endothelia surrounding capillaries were partially revealed by CD146 antigen expression in the cervical and lumbar spinal cords of G93A mice at initial and, more markedly, at late stages of disease.
Gene_expression (expression) of CD146 in endothelia associated with disease
1) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.72 Pain Relevance 0.14
Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.
Gene_expression (expressions) of CD146 in endothelial cells associated with disease and spinal cord
2) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.24 Pain Relevance 0.15
In the lumbar spinal cord of G93A mice at initial (Figure 10D, E) and late (Figure 10F, G) stages of disease, decreased or unclear CD146 antigen expression was noted in endothelial cells.
Gene_expression (expression) of CD146 in endothelial cells associated with disease and spinal cord
3) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.80 Pain Relevance 0.16
Although CD146 antigen expression was detected in some endothelial cells of early symptomatic G93A mice, indistinct immunoreaction for CD146 was observed in G93A mice at end-stage of disease.
Gene_expression (expression) of CD146 in endothelial cells associated with disease
4) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.34 Pain Relevance 0.15
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.
Gene_expression (expressions) of CD146 in endothelial cells
5) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.67 Pain Relevance 0.11
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB were found which may relate to vascular leakage.


Gene_expression (expressions) of CD146 in endothelial cells
6) Confidence 0.58 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.28 Pain Relevance 0.08
In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).
Neg (negative) Gene_expression (negative) of CD146 in hematopoietic cells associated with skin cancer and adhesions
7) Confidence 0.58 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.30 Pain Relevance 0
Herein, we used flow cytometry, immunoblot analysis, and immunocytostaining analysis to demonstrate that SHED at passage 3 expressed many mesenchymal surface markers, including STRO-1, SSEA4, CD73, CD105, CD146, and CD166 but were negative for CD34 and CD45 (Figures 1A-C).
Gene_expression (expressed) of CD146
8) Confidence 0.24 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0
We found that SHED are capable of differentiating into osteogenic and adipogenic cells, expressing mesenchymal surface molecules (STRO-1, CD146, SSEA4, CD73, CD105, and CD166), and activating multiple signaling pathways, including TGF?
Gene_expression (expressing) of CD146 in SHED
9) Confidence 0.24 Published 2010 Journal Stem Cell Res Ther Section Abstract Doc Link PMC2873699 Disease Relevance 0.33 Pain Relevance 0
In comparison to BMMSCs, SHED expressed significantly higher levels of STRO-1 and CD146, and lower levels of CD105 (Figure 1A).
Gene_expression (expressed) of CD146
10) Confidence 0.24 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.03

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