INT215899

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.96
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1)
intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)
Anatomy Link Frequency
endothelial cells 6
spinal cords 2
cingulate cortex 1
posterior 1
Slc2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 200 99.84 Very High Very High Very High
Inflammation 30 94.44 High High
chemokine 1 93.04 High High
cytokine 1 92.44 High High
Central nervous system 53 85.28 High High
Inflammatory response 5 13.04 Low Low
anesthesia 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 15 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 280 99.72 Very High Very High Very High
Cerebral Edema 15 97.32 Very High Very High Very High
INFLAMMATION 35 94.44 High High
Diabetes Mellitus 10 87.12 High High
Alzheimer's Dementia 5 85.08 High High
Motor Neuron Diseases 180 81.52 Quite High
Nerve Degeneration 30 81.20 Quite High
Insulin Resistance 2 77.28 Quite High
Congenital Anomalies 15 68.52 Quite High
Death 11 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This downregulation of Glut-1 expression in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.
Negative_regulation (downregulation) of Gene_expression (expression) of Glut-1 in endothelial cells
1) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.50 Pain Relevance 0.03
Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.
Negative_regulation (Downregulation) of Gene_expression (expressions) of Glut-1 in endothelial cells associated with disease and spinal cord
2) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.25 Pain Relevance 0.15
In the present study, we found low and mostly absent expression of Glut-1 in capillaries of both cervical and lumbar spinal cords of G93A mice at early and late stages of disease.
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of Glut-1 in spinal cords associated with disease
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.46 Pain Relevance 0.03
Alternatively, decreased Glut-1 expression may result from aggravated alterations of the BSCB in G93A mice.
Negative_regulation (decreased) of Gene_expression (expression) of Glut-1
4) Confidence 0.38 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.52 Pain Relevance 0.04
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB were found which may relate to vascular leakage.


Negative_regulation (downregulation) of Gene_expression (expressions) of Glut-1 in endothelial cells
5) Confidence 0.32 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.29 Pain Relevance 0.08
AD patients also characteristically feature a decrease in basal cerebral glucose utilization (CGU) in parietotemporal and posterior cingulate cortex (Fukuyama et al., 1994; Mosconi et al., 2004; Langbaum et al., 2009), altered neurometabolic coupling (Melrose et al., 2009), and reduced levels and activity of the endothelial glucose transporter 1 (GLUT-1) that delivers glucose to the brain from the blood (Kalaria and Harik, 1989; Simpson et al., 1994).
Negative_regulation (decrease) of in posterior Gene_expression (levels) of GLUT-1 in cingulate cortex associated with disease
6) Confidence 0.06 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.94 Pain Relevance 0.22

General Comments

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