INT2159

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 20
Speculated 32
Reported most in Abstract
Documents 200
Total Number 232
Disease Relevance 13.28
Pain Relevance 99.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
hypothalamus 26
neurons 26
pituitary 22
gonadal 14
preoptic area 12
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 592 100.00 Very High Very High Very High
Opioid 266 100.00 Very High Very High Very High
antagonist 187 100.00 Very High Very High Very High
Morphine 179 100.00 Very High Very High Very High
opiate 156 100.00 Very High Very High Very High
gABA 148 100.00 Very High Very High Very High
agonist 138 100.00 Very High Very High Very High
Dopamine 111 100.00 Very High Very High Very High
Endogenous opioid 87 100.00 Very High Very High Very High
Enkephalin 81 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 48 100.00 Very High Very High Very High
Galactorrhea 47 100.00 Very High Very High Very High
Pituitary Cancer 5 100.00 Very High Very High Very High
Stress 28 99.84 Very High Very High Very High
Chronic Renal Failure 2 99.80 Very High Very High Very High
Precocious Puberty 43 99.32 Very High Very High Very High
Uremia 33 99.32 Very High Very High Very High
Eating Disorder 7 99.20 Very High Very High Very High
Reprotox - General 2 2 97.44 Very High Very High Very High
Delayed Puberty 1 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abundant evidence suggests that opiatergic neurons play an important intermediary role in the regulation of LHRH release by ovarian steroids; however, it is unclear whether opiates communicate directly or indirectly with LHRH neurons.
Regulation (role) of Localization (release) of LHRH in neurons associated with opiate
1) Confidence 0.62 Published 1997 Journal Endocrinology Section Abstract Doc Link 9075729 Disease Relevance 0 Pain Relevance 0.25
Supernatants from the incubate were used to coincubate pituitaries in order to study the effect on luteinizing hormone release.
Regulation (effect) of Localization (release) of luteinizing hormone
2) Confidence 0.62 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 7043300 Disease Relevance 0.08 Pain Relevance 0.66
These results suggest a role for protein kinase C in regulating the release of GnRH.
Regulation (regulating) of Localization (release) of GnRH associated with kinase c
3) Confidence 0.62 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1475011 Disease Relevance 0 Pain Relevance 0.45
In vivo secretion of LHRH in ovariectomized rats is regulated by a possible autofeedback mechanism.
Spec (possible) Regulation (regulated) of Localization (secretion) of LHRH
4) Confidence 0.62 Published 1987 Journal Neuroendocrinology Section Title Doc Link 3302744 Disease Relevance 0 Pain Relevance 0.22
Alterations in the opioid control of LHRH release from hypothalami isolated from aged male rats.
Regulation (control) of Localization (release) of LHRH associated with narcan and opioid
5) Confidence 0.62 Published 1998 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Title Doc Link 9597043 Disease Relevance 0.15 Pain Relevance 0.46
The intrahypothalamic site(s) of endogenous opioid regulation of GnRH secretion remains to be resolved.
Regulation (regulation) of Localization (secretion) of GnRH associated with endogenous opioid
6) Confidence 0.62 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.05
NAL did not significantly alter K+-induced GnRH release.
Neg (not) Regulation (alter) of Localization (release) of GnRH associated with narcan
7) Confidence 0.62 Published 1988 Journal Endocrinology Section Abstract Doc Link 3058463 Disease Relevance 0 Pain Relevance 1.61
Moreover, our results are consistent with the hypothesis that the release of LHRH in the rat is regulated by the hypothalamic noradrenergic system, which is in turn modulated in some, as yet undetermined, fashion by opioid peptides.
Regulation (regulated) of Localization (release) of LHRH associated with opioid
8) Confidence 0.62 Published 1987 Journal Brain Res. Bull. Section Abstract Doc Link 2820553 Disease Relevance 0 Pain Relevance 0.31
Since the antagonist apparently exerts no important effects on the pituitary, the reasonable assumption has been made that it elevates gonadotropin levels by affecting the release of LH-releasing hormone (LHRH) from the hypothalamus.
Regulation (affecting) of Localization (release) of LHRH in hypothalamus associated with antagonist
9) Confidence 0.62 Published 1985 Journal Life Sci. Section Abstract Doc Link 3894852 Disease Relevance 0 Pain Relevance 0.51
The present data suggest that the endogenous opioid peptide may participate in the regulation of GnRH release under a particular steroid milieu, and the inhibitory action of endogenous opioid peptide seems to require the mediation of adrenergic neurotransmission, presumably through alpha-adrenergic receptor.
Spec (may) Regulation (participate) of Localization (release) of GnRH associated with endogenous opioid
10) Confidence 0.62 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1665001 Disease Relevance 0.06 Pain Relevance 0.49
Opioid-adrenergic-steroid connection in regulation of luteinizing hormone secretion in the rat.
Regulation (regulation) of Localization (secretion) of luteinizing hormone associated with opioid
11) Confidence 0.62 Published 1984 Journal Neuroendocrinology Section Title Doc Link 6328348 Disease Relevance 0 Pain Relevance 0.35
We also stress that these represent only a small subset of the neural and endocrine factors which regulate the secretion or actions of LHRH.
Regulation (regulate) of Localization (secretion) of LHRH in neural associated with stress
12) Confidence 0.62 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745827 Disease Relevance 0.10 Pain Relevance 0.10
These results strongly suggest that the NA input to the PO/AH is regulated by endogenous opioid peptides, and provide an anatomical substrate to explain opioid-NA interactions in the control of gonadotrophin releasing hormone (GnRH) and gonadotrophin secretion.
Regulation (control) of Localization (secretion) of GnRH associated with endogenous opioid and opioid
13) Confidence 0.62 Published 1991 Journal Exp Brain Res Section Abstract Doc Link 1653147 Disease Relevance 0 Pain Relevance 0.44
These findings suggest that the inhibition of pituitary gonadotropin secretion in experimental uremia is likely to be due to a functional defect in suprahypothalamic regulation of GnRH secretion rather than an intrinsic defect in the GnRH-secreting neurons.
Regulation (regulation) of Localization (secretion) of GnRH in neurons associated with uremia
14) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758577 Disease Relevance 0.64 Pain Relevance 0.27
Defective regulation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion is the primary defect leading to the inhibition of pituitary gonadotropin secretion and its consequences such as androgen deficiency and infertility in experimental uremia.
Regulation (regulation) of Localization (secretion) of GnRH in pituitary associated with reprotox - general 3 and uremia
15) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758577 Disease Relevance 0.32 Pain Relevance 0
Therefore, in order to clarify the mechanisms of aberrant regulation of hypothalamic GnRH secretion in experimental uremia, we examined basal secretion of GnRH from mediobasal hypothalamus (MBH) in vitro and the GnRH-secretory responses to naloxone, an opiate receptor antagonist in experimental uremia.
Regulation (regulation) of Localization (secretion) of GnRH in MBH associated with antagonist, narcan, opiate and uremia
16) Confidence 0.62 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758577 Disease Relevance 0.62 Pain Relevance 0.19
Opioid peptides modulate luteinizing hormone secretion during sexual maturation.
Regulation (modulate) of Localization (secretion) of luteinizing hormone associated with opioid
17) Confidence 0.62 Published 1979 Journal Science Section Title Doc Link 424743 Disease Relevance 0 Pain Relevance 0.52
The effects of an opiate receptor antagonist, naloxone, on the in vivo release of luteinizing hormone releasing hormone (LHRH) in ovariectomized and intact female rats were examined using push-pull perfusion.
Spec (examined) Regulation (effects) of Localization (release) of LHRH associated with antagonist, narcan and opiate
18) Confidence 0.62 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3135508 Disease Relevance 0 Pain Relevance 0.35
The GABA(A) receptor antagonist bicuculline used alone at a concentration of 20 microM caused no significant changes in the pulsatile GnRH release, but when used in combination with 500 nM of nicotine, bicuculline blocked the nicotine inhibition of GnRH release.
Neg (no) Regulation (changes) of Localization (release) of GnRH associated with gaba, nicotine and antagonist
19) Confidence 0.62 Published 2004 Journal Psychoneuroendocrinology Section Abstract Doc Link 15110924 Disease Relevance 0 Pain Relevance 0.74
The objective of this study was to determine if endogenous opioid peptides (EOPs) influence the pattern of pulsatile luteinizing hormone (LH) secretion on days 6-8, 14-16 and 22 of gestation in the rat.
Regulation (influence) of Localization (secretion) of luteinizing hormone associated with endogenous opioid
20) Confidence 0.61 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3323939 Disease Relevance 0 Pain Relevance 0.25

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