INT215900

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.65
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mcam) plasma membrane (Mcam)
Anatomy Link Frequency
endothelial cells 4
endothelia 2
Mcam (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 120 99.84 Very High Very High Very High
Inflammation 12 74.48 Quite High
Central nervous system 30 60.32 Quite High
Inflammatory response 3 53.76 Quite High
Multiple sclerosis 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 138 97.56 Very High Very High Very High
Motor Neuron Diseases 108 96.60 Very High Very High Very High
Nerve Degeneration 18 81.20 Quite High
INFLAMMATION 15 74.48 Quite High
Pathologic Processes 3 71.44 Quite High
Stroke 6 70.88 Quite High
Death 6 67.52 Quite High
Cerebral Edema 9 65.28 Quite High
Targeted Disruption 9 46.16 Quite Low
Congenital Anomalies 9 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.
Negative_regulation (downregulation) of Gene_expression (expressions) of CD146 in endothelial cells
1) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.68 Pain Relevance 0.13
Another of our findings was that endothelia surrounding capillaries were partially revealed by CD146 antigen expression in the cervical and lumbar spinal cords of G93A mice at initial and, more markedly, at late stages of disease.
Negative_regulation (revealed) of Gene_expression (expression) of CD146 in endothelia associated with disease
2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.72 Pain Relevance 0.14
Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.
Negative_regulation (Downregulation) of Gene_expression (expressions) of CD146 in endothelial cells associated with disease and spinal cord
3) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.25 Pain Relevance 0.15

General Comments

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