INT215921

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.80
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
leukocyte 1
microglia 1
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 97.44 Very High Very High Very High
metalloproteinase 260 91.36 High High
Central nervous system 120 85.52 High High
Inflammatory mediators 4 83.20 Quite High
chemokine 24 81.04 Quite High
Spinal cord 36 79.96 Quite High
glial activation 4 75.68 Quite High
Inflammation 24 19.20 Low Low
Multiple sclerosis 12 7.48 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 204 99.56 Very High Very High Very High
Sprains And Strains 8 98.44 Very High Very High Very High
Disease 24 96.56 Very High Very High Very High
Bordatella Infection 12 88.88 High High
Targeted Disruption 68 83.92 Quite High
INFLAMMATION 28 83.20 Quite High
Injury 40 77.76 Quite High
Cancer 20 22.56 Low Low
Malignant Neoplastic Disease 4 15.80 Low Low
Paralysis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, this shows that the pattern of MT-MMP regulation in severe EAE is independent of mouse strain, myelin antigen, and use of adjuvant in disease induction.


Regulation (regulation) of MT-MMP associated with multiple sclerosis, disease and sprains and strains
1) Confidence 0.33 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.95 Pain Relevance 0.20
However, no statistically significant change in expression by microglia of MMP-15 (Fig. 6B), or any other MT-MMP (data not shown) was observed in response to IFN?
Neg (no) Regulation (change) of MT-MMP in microglia
2) Confidence 0.20 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.37 Pain Relevance 0.31
MT-MMP regulation in neuroinflammation does not relate to expression of the proinflammatory cytokines TNF?
Regulation (regulation) of MT-MMP associated with cytokine
3) Confidence 0.20 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.57 Pain Relevance 0.53
We also investigate the relationship between MT-MMP regulation, leukocyte infiltration, and expression of the proinflammatory cytokines TNF?
Spec (investigate) Regulation (regulation) of MT-MMP in leukocyte associated with cytokine
4) Confidence 0.20 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.92 Pain Relevance 0.66

General Comments

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