INT215923

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 9.86
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mog)
Anatomy Link Frequency
T cells 2
B cells 1
brain 1
Astrocytes 1
oligodendrocyte 1
Mog (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 145 99.40 Very High Very High Very High
metalloproteinase 65 99.22 Very High Very High Very High
Inflammation 151 99.12 Very High Very High Very High
Neuritis 109 99.04 Very High Very High Very High
Multiple sclerosis 365 96.56 Very High Very High Very High
Central nervous system 337 91.68 High High
cytokine 80 88.16 High High
chemokine 14 86.80 High High
Demyelination 27 68.48 Quite High
Inflammatory marker 2 61.72 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 515 99.96 Very High Very High Very High
Disease 392 99.52 Very High Very High Very High
INFLAMMATION 166 99.12 Very High Very High Very High
Optic Neuritis 105 99.04 Very High Very High Very High
Neuromyelitis Optica 865 98.48 Very High Very High Very High
Targeted Disruption 102 97.72 Very High Very High Very High
General Immunology 1 95.20 Very High Very High Very High
Demyelinating Disease 224 90.08 High High
Adhesions 6 85.84 High High
Central Nervous System Disease 35 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of all six MT-MMPs has now been studied in both actively induced and adoptively transferred MOG35–55 EAE in B6 mice with severe (grade 4) disease (Fig. 1).
Positive_regulation (induced) of MOG35 associated with multiple sclerosis, metalloproteinase and disease
1) Confidence 0.19 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.79 Pain Relevance 0.17
Increased activation of MOG-specific T cells was thought to be due to enhanced antigen presentation by MOG-specific B cells, while the role of isotype-switching was not investigated [130].
Positive_regulation (activation) of MOG in B cells
2) Confidence 0.19 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.24 Pain Relevance 0.23
Interestingly, treatments to induce changes in the BBB increase the manifestation of ON, but not of EAE, suggesting that the access of MOG-activated T cell to the spinal cord or brain is not sufficient to cause EAE.
Positive_regulation (activated) of MOG in brain associated with multiple sclerosis, neuritis and spinal cord
3) Confidence 0.19 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.41 Pain Relevance 0.70
In the present study, we demonstrate that Olig1 deficiency, or reduced expression of MOG, MBP and MAG caused by Olig1 deficiency, delayed the onset of EAE.
Positive_regulation (caused) of MOG associated with multiple sclerosis
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.87 Pain Relevance 0.29
If the autoantibodies are not pathogenic per se, it may be that the ability of self-reactive B cells to capture their cognate antigen and, in the case of AQP4 or MOG, present antigen to normally non-reactive MOG or AQP4-specific T cells, instigates NMO.
Positive_regulation (reactive) of MOG in T cells associated with neuromyelitis optica
5) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.94 Pain Relevance 0.27
Other MOG-models readily induce EAE indicating MOG-specific T cells can be pathogenic.


Positive_regulation (induce) of MOG in T cells associated with multiple sclerosis
6) Confidence 0.16 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.69 Pain Relevance 0.67
Astrocytes from mice deficient in Class II transactivator (CIITA) failed to activate MOG-specific CD4+ T cells due to a lack of MHC Class II expression [163, 203].
Neg (failed) Positive_regulation (activate) of MOG-specific in Astrocytes
7) Confidence 0.15 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.27 Pain Relevance 0.33
Immunologic studies focused on myelin protein specific immune responses including those directed against myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte protein (MOG).
Positive_regulation (directed) of myelin oligodendrocyte protein in oligodendrocyte
8) Confidence 0.07 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.66 Pain Relevance 0.52

General Comments

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