INT215926

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 5.33
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
microglia 4
spinal cord 2
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 81 99.68 Very High Very High Very High
Central nervous system 270 99.14 Very High Very High Very High
cytokine 90 98.00 Very High Very High Very High
metalloproteinase 585 96.88 Very High Very High Very High
glial activation 9 78.32 Quite High
Inflammation 54 77.68 Quite High
chemokine 54 73.80 Quite High
Inflammatory mediators 9 44.08 Quite Low
Multiple sclerosis 27 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 459 99.84 Very High Very High Very High
Targeted Disruption 153 99.62 Very High Very High Very High
Disease 54 87.96 High High
INFLAMMATION 63 77.68 Quite High
Injury 90 76.32 Quite High
Sprains And Strains 18 34.00 Quite Low
Bordatella Infection 27 30.32 Quite Low
Cancer 45 25.12 Quite Low
Necrosis 9 24.64 Low Low
Paralysis 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
does not regulate microglial MT-MMP expression in vitro
Regulation (regulate) of Gene_expression (expression) of MT-MMP
1) Confidence 0.45 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.62 Pain Relevance 0.20
After PTx-induced parenchymal CNS infiltration in CCL2 Tg mice, we noted no change in MT-MMP expression.
Neg (no) Regulation (change) of Gene_expression (expression) of MT-MMP associated with targeted disruption and central nervous system
2) Confidence 0.45 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.50 Pain Relevance 0.34
The different regulation of MT-MMP expression in these three in vivo models of neuroinflammation could potentially be due to different involvement of glial responses and cytokine levels.
Regulation (regulation) of Gene_expression (expression) of MT-MMP associated with cytokine
3) Confidence 0.45 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.55 Pain Relevance 0.37
as possible candidates for regulators of MT-MMP expression.
Spec (possible) Regulation (regulators) of Gene_expression (expression) of MT-MMP
4) Confidence 0.45 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.52 Pain Relevance 0.43
did not lead to different regulation of MT-MMP expression in EAE spinal cord.


Regulation (regulation) of Gene_expression (expression) of MT-MMP in spinal cord associated with multiple sclerosis and spinal cord
5) Confidence 0.45 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.64 Pain Relevance 0.25
regulates MT-MMP expression by microglia, we isolated microglia from CNS of adult WT and IFN?
Regulation (regulates) of Gene_expression (expression) of MT-MMP in microglia associated with central nervous system
6) Confidence 0.33 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.60 Pain Relevance 0.20
did not change the regulation of MT-MMP expression in EAE.
Regulation (regulation) of Gene_expression (expression) of MT-MMP associated with multiple sclerosis
7) Confidence 0.33 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.67 Pain Relevance 0.38
did not change MT-MMP expression by microglia in vitro.


Neg (not) Regulation (change) of Gene_expression (expression) of MT-MMP in microglia
8) Confidence 0.33 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.67 Pain Relevance 0.44
MMP-15, 17 and 25 were statistically significantly downregulated following stab lesion, whereas no significant change in expression of MMP-14, 16 and 24 was noted (Fig. 4A–F).


Neg (no) Regulation (change) of Gene_expression (expression) of MMP-14
9) Confidence 0.20 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.57 Pain Relevance 0.53

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