INT215941

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 7.00
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP25) extracellular region (MMP25) proteinaceous extracellular matrix (MMP25)
plasma membrane (MMP25)
Anatomy Link Frequency
colon 2
leukocytes 1
neutrophils 1
MMP25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 99.24 Very High Very High Very High
metalloproteinase 249 97.88 Very High Very High Very High
Spinal cord 9 88.72 High High
Central nervous system 30 81.64 Quite High
chemokine 18 61.84 Quite High
cytokine 18 59.84 Quite High
Inflammatory mediators 1 37.24 Quite Low
rheumatoid arthritis 28 26.00 Quite Low
Multiple sclerosis 19 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 157 99.84 Very High Very High Very High
Glioma 8 99.68 Very High Very High Very High
Colon Cancer 16 99.28 Very High Very High Very High
INFLAMMATION 67 99.24 Very High Very High Very High
Disease Progression 8 99.24 Very High Very High Very High
Prostate Cancer 4 97.24 Very High Very High Very High
Metastasis 36 95.80 Very High Very High Very High
Adenocarcinoma 4 92.08 High High
Ovarian Cancer 4 88.24 High High
Breast Cancer 24 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-25 is also known as leukolysin and is expressed by neutrophils [26,33].
Gene_expression (expressed) of leukolysin in neutrophils
1) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.38 Pain Relevance 0.39
There is an excellent review on the properties and expression of MMP-17 and MMP-25 in cancer published by Sohail and coworkers [57].
Gene_expression (expression) of MMP-25 associated with cancer
2) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.68 Pain Relevance 0.22
Human MMP-25 is expressed by leukocytes and neutrophils, and in colon, urothelial, brain, and prostate cancers [59, 119–122].
Gene_expression (expressed) of MMP-25 in colon associated with prostate cancer
3) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.75 Pain Relevance 0.19
Expression of MMP-25 in HCT-116 human colon cancer cells promotes tumorigenesis in nude mice.
Gene_expression (Expression) of MMP-25 in colon associated with colon cancer
4) Confidence 0.27 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.58 Pain Relevance 0.25
Strong MMP-25 staining was detected in inflammatory-like cells consistent with the known expression of MMP-25 in leukocytes [64].

6.3.

Gene_expression (expression) of MMP-25 in leukocytes associated with inflammation
5) Confidence 0.21 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.61 Pain Relevance 0.35

General Comments

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