INT215947

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
Anatomy Link Frequency
impression 2
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 41 100.00 Very High Very High Very High
Hyperinsulinism 2 100.00 Very High Very High Very High
Targeted Disruption 10 54.96 Quite High
Anxiety Disorder 5 31.24 Quite Low
Hypertrophy 4 23.68 Low Low
Mental Disorders 5 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Weight Loss 3 5.00 Very Low Very Low Very Low
Xerostomia 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rate of improvement according to the psychiatrist rated clinical global impression (CGI-I) for ADHD was statistically significantly higher for both IR-MPH (tid) (?
Positive_regulation (for) of Gene_expression (higher) of IR-MPH in impression associated with attention deficit hyperactivity disorder
1) Confidence 0.14 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.10 Pain Relevance 0
The increased insulin receptor gene expression in women could be related to the higher GRB10 expression (see Discussion).
Positive_regulation (increased) of Gene_expression (expression) of insulin receptor associated with hyperinsulinism
2) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.10 Pain Relevance 0
GRB10 also interferes with insulin signaling [31], [32], in part by mediating degradation of the insulin receptor [33], but the 3-fold increase in insulin receptor gene expression in women (Table 2) could serve to minimize any negative effect on insulin sensitivity that increased GRB10 expression might have.
Positive_regulation (increase) of Gene_expression (expression) of insulin receptor
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.05 Pain Relevance 0

General Comments

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