INT215972

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr3) intracellular (Egr3) DNA binding (Egr3)
Anatomy Link Frequency
dentate gyrus 1
Egr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 78.64 Quite High
Paresthesia 2 9.52 Low Low
long-term potentiation 16 5.00 Very Low Very Low Very Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
opiate 4 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 40 97.94 Very High Very High Very High
Recurrence 20 96.36 Very High Very High Very High
Hypercalcemia 22 91.20 High High
Disease 10 87.44 High High
Chronic Renal Failure 10 85.44 High High
Convulsion 10 33.60 Quite Low
Hypocalcemia 14 30.40 Quite Low
Cognitive Disorder 40 22.08 Low Low
Anxiety Disorder 40 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All blots were probed for regulation of Egr1, Egr2, Egr3 and Actin; antibodies were stripped for the blot with Reblot (Chemicon Intentional) and three replicates per sample were made.
Regulation (regulation) of Egr3
1) Confidence 0.60 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.17 Pain Relevance 0
Also in keeping with the pattern of results observed in the dentate gyrus, there was significant induction of Egr1 in all genotypes following MECS compared with non-stimulated mice (t-test, all p values <0.05; Figures 7A and 7D), and no significant regulation of Egr3 at this time point (t-test, all p values >0.05; Figures 7C and 7D).
Neg (no) Regulation (regulation) of Egr3 in dentate gyrus associated with shock
2) Confidence 0.26 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.56 Pain Relevance 0.04
Therefore better estimates are needed and a pilot multicentred randomized controlled trial comparing 50 versus 50 randomized patients seems feasible and ethical to assess the recurrence rate of both methods after three years in specialized centres.


Regulation (controlled) of pilot associated with recurrence
3) Confidence 0.05 Published 2007 Journal Trials Section Body Doc Link PMC2075519 Disease Relevance 0.22 Pain Relevance 0
TOPAR PILOT is a randomized controlled multicentred pilot trial to generate high quality evidence comparing the outcomes of TPTX+AT vs.
Regulation (controlled) of PILOT
4) Confidence 0.03 Published 2007 Journal Trials Section Body Doc Link PMC2075519 Disease Relevance 0.26 Pain Relevance 0

General Comments

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