INT2160

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 4.58
Pain Relevance 11.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
blood 2
follicle 2
pituitary 2
lever 2
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 72 100.00 Very High Very High Very High
opiate 27 100.00 Very High Very High Very High
Morphine 24 100.00 Very High Very High Very High
dexamethasone 7 100.00 Very High Very High Very High
Catecholamine 7 99.76 Very High Very High Very High
agonist 19 99.52 Very High Very High Very High
Antinociceptive 2 99.38 Very High Very High Very High
noradrenaline 7 98.94 Very High Very High Very High
Opioid 22 98.90 Very High Very High Very High
Clonidine 2 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 39 100.00 Very High Very High Very High
Depression 4 100.00 Very High Very High Very High
Body Weight 3 98.90 Very High Very High Very High
Stress 18 94.92 High High
Starvation 3 89.92 High High
Endometriosis (extended) 18 83.44 Quite High
Attention Deficit Hyperactivity Disorder 1 83.12 Quite High
Hypothermia 1 75.24 Quite High
Toxicity 3 64.32 Quite High
Frailty 14 58.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our demonstration of a maturation-related reduction in opiate inhibition of LH suggests a critical role for endogenous (hypothalamic?)
Negative_regulation (reduction) of Negative_regulation (inhibition) of LH associated with opiate
1) Confidence 0.58 Published 1983 Journal Endocrinology Section Abstract Doc Link 6409589 Disease Relevance 0 Pain Relevance 0.48
Injection of the catecholamine precursor L-dopa (100 mg/kg) can prevent the increase of plasma corticosterone, but not the decrease of LH.
Negative_regulation (prevent) of Neg (not) Negative_regulation (decrease) of LH in plasma associated with catecholamine
2) Confidence 0.58 Published 1982 Journal Acta Endocrinol. Section Abstract Doc Link 7113589 Disease Relevance 0.26 Pain Relevance 0.63
Naloxone administration prevented the hypoglycaemia-induced inhibition of LH pulses.
Negative_regulation (prevented) of Negative_regulation (inhibition) of LH associated with hypoglycemia and narcan
3) Confidence 0.57 Published 1997 Journal J. Neuroendocrinol. Section Abstract Doc Link 9419838 Disease Relevance 0.76 Pain Relevance 0.30
Naloxone also prevented testosterone's negative feedback inhibition of serum LH in the castrated male rat.
Negative_regulation (prevented) of Negative_regulation (inhibition) of LH associated with narcan
4) Confidence 0.51 Published 1979 Journal Endocrinology Section Abstract Doc Link 374068 Disease Relevance 0 Pain Relevance 0.61
In castrated male rats treated with testosterone propionate (TP), nalmefene (10 mg/kg) reversed the androgen negative feedback on LH secretion; surprisingly, when higher doses (25 and 50 mg/kg) were injected, the compound lost its ability to antagonize the testosterone-induced inhibition of LH levels.
Negative_regulation (lost) of Negative_regulation (inhibition) of LH
5) Confidence 0.43 Published 1985 Journal Steroids Section Abstract Doc Link 3842024 Disease Relevance 0 Pain Relevance 0.66
These data indicate that treatment with EBP, which stimulates a preovulatory-like LH surge, decreases the ability of MS to induce hypothermic, antinociceptive, and behavioral responses and abolishes its capacity to suppress LH release.
Negative_regulation (abolishes) of Negative_regulation (suppress) of LH associated with antinociceptive
6) Confidence 0.43 Published 1988 Journal Endocrinology Section Abstract Doc Link 2836173 Disease Relevance 0.16 Pain Relevance 0.64
This congruence of the temporal bimodal profiles in the response functions of these two different behavioral experiments strongly suggests that the same integrative mechanism underlies both LH inhibition of NGC escape and lever-pressing for LH trains during inescapable stimulation of NGC.
Negative_regulation (underlies) of Negative_regulation (inhibition) of LH in lever
7) Confidence 0.41 Published 1982 Journal Brain Res. Section Abstract Doc Link 7188027 Disease Relevance 0 Pain Relevance 0.08
The existence of a putative CRF-opioid interaction in the inhibitory control of LH secretion was supported by the effectiveness of naloxone to reverse the CRF-induced decrease in LH levels in EB-treated and untreated OVX rats.
Negative_regulation (reverse) of Negative_regulation (decrease) of LH associated with narcan and opioid
8) Confidence 0.40 Published 1987 Journal Endocrinology Section Abstract Doc Link 3542513 Disease Relevance 0 Pain Relevance 0.44
This effect was characterized by a 10 fold reduction in the ED50 (1.26 mg/kg versus 0.13 mg/kg in saline- and naloxone-pretreated rats, respectively) and much greater depressions in serum LH levels at each dose of morphine.
Negative_regulation (reduction) of Negative_regulation (depressions) of LH associated with depression, narcan and morphine
9) Confidence 0.38 Published 1984 Journal Life Sci. Section Abstract Doc Link 6090834 Disease Relevance 0.27 Pain Relevance 1.10
Naltrexone treatment did not directly affect pituitary LH storage, but prevented EB-induced depletion of pituitary LH pools; morphine blocked this action of naltrexone.
Negative_regulation (prevented) of Negative_regulation (depletion) of LH in pituitary associated with morphine
10) Confidence 0.38 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3808218 Disease Relevance 0 Pain Relevance 0.73
In a second set of experiments, administration of naloxone (2 mg/kg body weight) increased LH levels (P less than 0.05) and similarly reversed the inhibitory effect of dexamethasone on LH.
Negative_regulation (reversed) of Negative_regulation (effect) of LH in body associated with body weight, narcan and dexamethasone
11) Confidence 0.37 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2671240 Disease Relevance 0.17 Pain Relevance 0.46
A third experiment, in which short term castrates were pretreated with an opioid antibody and then with CRF, resulted in a significant reduction of the CRF-induced reduction of serum LH levels.
Negative_regulation (reduction) of Negative_regulation (reduction) of serum LH associated with opioid
12) Confidence 0.37 Published 1988 Journal Endocrinology Section Abstract Doc Link 3257730 Disease Relevance 0 Pain Relevance 0.53
In most experimental groups, LH responses after naloxone were clearly unrelated to pituitary LH responsiveness to LHRH, which indicates that the opioid antagonist was acting via the central nervous system.
Negative_regulation (unrelated) of Negative_regulation (responsiveness) of LH in central nervous system associated with antagonist, narcan, central nervous system and opioid
13) Confidence 0.37 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6368728 Disease Relevance 0 Pain Relevance 0.46
As plasma E2 and P levels increased between D1 and D2, mean blood LH levels decreased due solely to a decrease in LH pulse amplitude as frequency remained stable.
Negative_regulation (decreased) of Negative_regulation (decrease) of LH in blood
14) Confidence 0.36 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3362306 Disease Relevance 0 Pain Relevance 0.24
On the other hand, prior blockade of the CRH receptors with alpha-helical CRH-(9-41) (25 or 100 micrograms/rat) was ineffective in reversing the inhibitory LH response of NPY (0.125 nmol).
Negative_regulation (reversing) of Negative_regulation (response) of LH
15) Confidence 0.36 Published 1993 Journal Endocrinology Section Abstract Doc Link 8344213 Disease Relevance 0 Pain Relevance 0.41
Injection of NA or alpha1-adrenergic agonist into the BNST strongly suppressed pulsatile LH secretion in OVX+E2 rats with a significant (P < 0.05) decrease in the mean LH level for 3 h and LH pulse frequency, but alpha2-and beta-agonists did not affect any of the LH pulse parameters.
Negative_regulation (suppressed) of Negative_regulation (decrease) of LH associated with agonist and noradrenaline
16) Confidence 0.34 Published 2006 Journal J. Reprod. Dev. Section Abstract Doc Link 16340166 Disease Relevance 0 Pain Relevance 0.63
A simultaneous treatment of mother animals with tyrosine--a catecholamine precursor--prevented the depletion of hypothalamic and pituitary beta-endorphin as well as in part the reduction of plasma LH levels in male fetuses.
Negative_regulation (prevented) of Negative_regulation (reduction) of LH in plasma associated with catecholamine
17) Confidence 0.29 Published 1989 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2532147 Disease Relevance 0.68 Pain Relevance 0.34
Alprazolam prevented hypoglycemia-induced inhibition of LH independent of an effect on glucose concentrations.
Negative_regulation (prevented) of Negative_regulation (inhibition) of LH associated with hypoglycemia
18) Confidence 0.29 Published 1997 Journal Neuroendocrinology Section Abstract Doc Link 9158066 Disease Relevance 0.76 Pain Relevance 0.37
Hypoglycemia-induced inhibition of LH and stimulation of ACTH secretion in the rhesus monkey is blocked by alprazolam.
Negative_regulation (blocked) of Negative_regulation (inhibition) of LH associated with narcan
19) Confidence 0.29 Published 1997 Journal Neuroendocrinology Section Title Doc Link 9158066 Disease Relevance 0.65 Pain Relevance 0.36
In contrast, naloxone did not prevent hypoglycemia-induced LH inhibition.
Negative_regulation (prevent) of Negative_regulation (inhibition) of LH associated with hypoglycemia and narcan
20) Confidence 0.29 Published 1997 Journal Neuroendocrinology Section Abstract Doc Link 9158066 Disease Relevance 0.61 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox