INT216011

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 3.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC2) signal transduction (TSC2) vesicle-mediated transport (TSC2)
Golgi apparatus (TSC2) nucleus (TSC2) intracellular (TSC2)
Anatomy Link Frequency
neuroendocrine cells 1
TSC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Watson Syndrome 3 99.96 Very High Very High Very High
Chordoma 131 99.20 Very High Very High Very High
Tuberous Sclerosis 6 98.88 Very High Very High Very High
Neurofibromatosis 3 98.32 Very High Very High Very High
Carcinoid 11 97.86 Very High Very High Very High
Hypoglycemia 37 96.36 Very High Very High Very High
Von Hippel-lindau Syndrome 1 86.40 High High
Neuroendocrine Cancer 7 85.04 High High
Hereditary Neoplastic Syndromes 2 82.76 Quite High
Gastrinoma 10 77.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TSC1/2 complex inhibits mTOR and is normally expressed in neuroendocrine cells.3 Patients with a defect in the TSC2 gene have tuberous sclerosis and are known to develop islet cell carcinoma.4 Neurofibromatosis is associated with the development of carcinoid tumors of the ampulla of Vater, duodenum, and mediastinum.5,6 The gene responsible for neurofibromatosis 1 (NF1) regulates the activity of TSC2.
Regulation (regulates) of TSC2 in neuroendocrine cells associated with hypoglycemia, carcinoid, tuberous sclerosis, neurofibromatosis and watson syndrome
1) Confidence 0.26 Published 2007 Journal Ann Surg Oncol Section Body Doc Link PMC2077912 Disease Relevance 2.32 Pain Relevance 0
The role in chordomagenesis of the Tuberous Sclerosis Complex (TSC) genes has been proved, but the extent of involvement of TSC1 and TSC2 oncosuppressors in chordoma remains to be assessed.
Regulation (involvement) of TSC2 associated with tuberous sclerosis and chordoma
2) Confidence 0.21 Published 2005 Journal Hered Cancer Clin Pract Section Abstract Doc Link PMC2837065 Disease Relevance 0.99 Pain Relevance 0

General Comments

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