INT216023

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.52
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
dorsal root 4
cortex 2
Mag (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.46 Very High Very High Very High
Sciatic nerve 88 96.28 Very High Very High Very High
Neuropathic pain 38 95.12 Very High Very High Very High
Demyelination 160 87.60 High High
spinal dorsal horn 6 83.44 Quite High
Spinal cord 6 68.60 Quite High
Catechol-O-methyltransferase 1 59.84 Quite High
dorsal root ganglion 14 56.08 Quite High
Inflammation 4 52.08 Quite High
intrathecal 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 45 99.82 Very High Very High Very High
Schizophrenia 62 99.28 Very High Very High Very High
Nervous System Injury 46 97.44 Very High Very High Very High
Neuropathic Pain 50 95.12 Very High Very High Very High
Demyelinating Disease 170 87.60 High High
Disease Susceptibility 4 60.88 Quite High
Ganglion Cysts 14 56.08 Quite High
INFLAMMATION 4 52.08 Quite High
Depression 5 38.04 Quite Low
Anxiety Disorder 14 37.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injury-induced MAG down-regulation in the dorsal root was slightly observed at day 1 (91.1 ± 7.1%/n = 3) and day 3 (91.8 ± 6.5%/n = 3) post-injury (Figure 4c).
Negative_regulation (down) of Negative_regulation (regulation) of MAG in dorsal root associated with injury
1) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 0.63 Pain Relevance 0.28
Furthermore, metalloproteinase inhibition did not affect MAG down-regulation in the dorsal root following intrathecally administered LPA [32], which mimics the nerve injury in terms of induction of neuropathic pain and its underlying mechanisms [8].
Neg (not) Negative_regulation (down) of Negative_regulation (regulation) of MAG in dorsal root associated with nervous system injury, neuropathic pain and metalloproteinase
2) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.12 Pain Relevance 0.98
Specifically, microarray expression studies and single-gene quantitative RT-PCR studies indicate a down-regulation of MAG in at least some schizophrenia cohorts [32], [33] and one preliminary study suggested that levels of RTN4 mRNA are also increased in the cortex of some individuals with chronic schizophrenia [34].
Negative_regulation (down) of Negative_regulation (regulation) of MAG in cortex associated with schizophrenia
3) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.77 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox