INT216030

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.78
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
stalk 1
Rtn4r (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 1 97.40 Very High Very High Very High
Central nervous system 28 95.40 Very High Very High Very High
Sciatic nerve 1 94.52 High High
depression 16 92.48 High High
Spinal cord 2 83.68 Quite High
imagery 4 43.08 Quite Low
Eae 28 16.64 Low Low
amygdala 8 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 248 99.64 Very High Very High Very High
Necrosis 4 98.44 Very High Very High Very High
Cancer 4 98.08 Very High Very High Very High
Injury 31 97.44 Very High Very High Very High
Depression 20 92.48 High High
Disease 44 91.20 High High
Disease Susceptibility 16 89.36 High High
Targeted Disruption 24 88.80 High High
Frailty 1 83.68 Quite High
Optic Nerve Injuries 3 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also identified rare non-synonymous changes within the RTN4R gene of schizophrenia patients but not in unaffected controls.
Positive_regulation (changes) of RTN4R associated with schizophrenia
1) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.90 Pain Relevance 0
The other non-synonymous variant we identified in one male patient, L347R, is positioned within the “stalk” of RTN4R that is required for p75 interaction.


Positive_regulation (required) of RTN4R in stalk
2) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.34 Pain Relevance 0.05
Activation of RTN4R initiates a cascade that leads to the activation of RhoA and, ultimately, the inhibition of axonal growth [5]–[7].
Positive_regulation (Activation) of RTN4R
3) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.40 Pain Relevance 0.14
As a result of this rearrangement, the Rtn4r mouse gene is located between the Prodh gene (?
Positive_regulation (result) of Rtn4r
4) Confidence 0.47 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.24 Pain Relevance 0
This feature, together with its in vitro activities, has confirmed Nogo-66 as a myelin-derived inhibitor to the axonal regeneration after injury.
Positive_regulation (confirmed) of Nogo-66 associated with injury
5) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.90 Pain Relevance 0.31

General Comments

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