INT216034

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.14
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
brains 2
oligodendrocytes 2
neurons 1
peripheral nervous system 1
Rtn4r (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 73 99.84 Very High Very High Very High
Sciatic nerve 3 99.20 Very High Very High Very High
Peripheral nervous system 6 96.80 Very High Very High Very High
Catechol-O-methyltransferase 4 68.88 Quite High
Spinal cord 25 68.72 Quite High
dorsal root ganglion 1 66.00 Quite High
withdrawal 4 47.84 Quite Low
depression 16 47.08 Quite Low
Eae 28 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 63 99.96 Very High Very High Very High
Schizophrenia 248 96.64 Very High Very High Very High
Psychosis 12 96.40 Very High Very High Very High
Injury 75 91.52 High High
Cicatrix 3 81.00 Quite High
Optic Nerve Injuries 12 69.36 Quite High
Frailty 3 68.72 Quite High
Glaucoma 4 67.00 Quite High
Ganglion Cysts 7 65.04 Quite High
Depression 20 47.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of Rtn4r-deficient mice
Gene_expression (Generation) of Rtn4r
1) Confidence 0.78 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.24 Pain Relevance 0
Generation of Rtn4r knockout mice
Gene_expression (Generation) of Rtn4r associated with targeted disruption
2) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.49 Pain Relevance 0
Moreover, alterations in the levels of RTN4R or two RTN4R ligands have been described in postmortem analyses of brains from individuals with schizophrenia.
Gene_expression (levels) of RTN4R in brains associated with schizophrenia
3) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.62 Pain Relevance 0.03
Moreover, alterations in the levels of RTN4R or two RTN4R ligands have been described in postmortem analyses of brains from individuals with schizophrenia.
Gene_expression (levels) of RTN4R in brains associated with schizophrenia
4) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.62 Pain Relevance 0.03
Nogo-66 is expressed on the surface of oligodendrocytes [2] and functions by binding to an axonal Nogo-66 receptor (NgR) [3].
Gene_expression (expressed) of Nogo-66 in oligodendrocytes
5) Confidence 0.59 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.78 Pain Relevance 0.30
Several myelin inhibitors of axonal growth, including Nogo-66, myelin-associated glycoprotein, and oligodendrocyte-myelin glycoprotein, exert their effects through NgR.
Gene_expression (exert) of NgR in oligodendrocyte
6) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.41 Pain Relevance 0
Nogo-66 is somewhat “fastidious” as regards to which environment it will express, as it is expressed in the myelin of a sciatic nerve transplant to the CNS but not in those to the peripheral nervous system (PNS).
Neg (not) Gene_expression (expressed) of Nogo-66 in peripheral nervous system associated with peripheral nervous system, central nervous system and sciatic nerve
7) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.91 Pain Relevance 0.33
Interestingly, these 3 structurally distinct myelin-associated inhibitors bind to the same receptor, ie, NgR, which is a GPI-anchored protein and is expressed in CNS neurons as well as in their axons (Josephson et al 2002; Wang 2002c).
Gene_expression (expressed) of NgR in neurons associated with central nervous system
8) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox