INT216035

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.21
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Rtn4r) plasma membrane (Rtn4r)
Anatomy Link Frequency
oligodendrocytes 2
vasculature 1
neurons 1
face 1
Rtn4r (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 71 97.84 Very High Very High Very High
Sciatic nerve 2 89.84 High High
Peripheral nervous system 5 85.04 High High
antidepressant 5 83.36 Quite High
depression 20 81.88 Quite High
dorsal root ganglion 1 62.00 Quite High
Spinal cord 23 60.16 Quite High
nMDA receptor 10 51.68 Quite High
imagery 11 48.84 Quite Low
Eae 35 22.40 Low Low
Disease Link Frequency Relevance Heat
Schizophrenia 310 99.80 Very High Very High Very High
Cancer 82 97.28 Very High Very High Very High
Disease 82 96.96 Very High Very High Very High
Disease Susceptibility 20 92.32 High High
Ovarian Cancer 100 91.80 High High
Apoptosis 10 84.60 Quite High
Injury 60 83.12 Quite High
Depression 25 81.88 Quite High
Stress 5 79.76 Quite High
Cicatrix 2 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The T134M variant we identified in one female patient is located in the concave face of the ligand-binding ectodomain of RTN4R, within the fourth LRR.
RTN4R Binding (binding) of in face
1) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.15 Pain Relevance 0.04
Stratification by sex provided weak evidence for an association between RTN4R and schizophrenia, which did not survive a conservative Bonferroni correction.
RTN4R Binding (association) of associated with schizophrenia
2) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.98 Pain Relevance 0
To evaluate association between the RTN4R gene and susceptibility to schizophrenia, we recruited participants from 312 Afrikaner families with at least one schizophrenic subject.
RTN4R Binding (association) of associated with schizophrenia
3) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.38 Pain Relevance 0
Behavioral characterization of Rtn4r-deficient mice following transient postnatal NMDAR blockade
Rtn4r Binding (characterization) of
4) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.62 Pain Relevance 0.15
Nogo-66 is expressed on the surface of oligodendrocytes [2] and functions by binding to an axonal Nogo-66 receptor (NgR) [3].
NgR Binding (binding) of in oligodendrocytes
5) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.89 Pain Relevance 0.31
Given the difficulties in assessing the significance of association to rare variants, primarily due to a lack of power [39], we sought to obtain additional supportive data by testing for independent association with common variants of RTN4R (Fig. 1A) in families with schizophrenia.
RTN4R Binding (association) of associated with schizophrenia
6) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.40 Pain Relevance 0.04
Nogo-66 is expressed on the surface of oligodendrocytes [2] and functions by binding to an axonal Nogo-66 receptor (NgR) [3].
Nogo-66 Binding (binding) of in oligodendrocytes
7) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.83 Pain Relevance 0.31
Interestingly, these 3 structurally distinct myelin-associated inhibitors bind to the same receptor, ie, NgR, which is a GPI-anchored protein and is expressed in CNS neurons as well as in their axons (Josephson et al 2002; Wang 2002c).
NgR Binding (bind) of in neurons associated with central nervous system
8) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0.29
Peptides containing the asparagines-glycine-arginine (NGR) motif, which binds to a specific isoform of CD13 exclusively found in angiogenic vessels, have been used to deliver various antitumor compounds to the tumor vasculature [130].
NGR Binding (binds) of in vasculature associated with cancer
9) Confidence 0.04 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.91 Pain Relevance 0

General Comments

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