INT216038

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) endoplasmic reticulum (Rtn4) plasma membrane (Rtn4)
protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
stalk 1
Rtn4 (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 2 82.64 Quite High
withdrawal 2 61.60 Quite High
depression 8 60.84 Quite High
Eae 14 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 124 100.00 Very High Very High Very High
Depression 10 60.84 Quite High
Anxiety Disorder 28 60.36 Quite High
Psychosis 6 44.96 Quite Low
Mental Disorders 2 39.56 Quite Low
Congenital Anomalies 8 31.96 Quite Low
Disease Susceptibility 8 30.36 Quite Low
Cognitive Disorder 16 19.48 Low Low
Digeorge Syndrome 2 17.12 Low Low
Heart Defects 2 15.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ectodomain is both necessary and sufficient for binding the RTN4 ligand [35] and the C-terminal domain containing the GPI sequence and the connecting “stalk” is required for interaction with at least one of the co-factors, p75 [36].
RTN4 Binding (binding) of in stalk
1) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.14 Pain Relevance 0.03
However, two preliminary reports described sex-specific associations between schizophrenia and common variants in the RTN4R gene [29], as well as its ligand RTN4 [30].
RTN4 Binding (associations) of associated with schizophrenia
2) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.67 Pain Relevance 0.10

General Comments

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