INT216040

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt, Prodh) oxidoreductase activity (Prodh) methyltransferase activity (Comt)
plasma membrane (Comt)
Comt (Mus musculus)
Prodh (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 2 100.00 Very High Very High Very High
withdrawal 2 80.84 Quite High
depression 8 80.08 Quite High
Central nervous system 10 18.32 Low Low
Eae 14 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 124 97.84 Very High Very High Very High
Depression 10 80.08 Quite High
Anxiety Disorder 28 79.60 Quite High
Psychosis 6 64.20 Quite High
Mental Disorders 2 58.80 Quite High
Congenital Anomalies 8 51.20 Quite High
Cognitive Disorder 16 38.72 Quite Low
Digeorge Syndrome 2 36.36 Quite Low
Heart Defects 2 34.48 Quite Low
Injury 6 18.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although, collectively, the human genetic and animal model studies designed to identify schizophrenia susceptibility genes from the 22q11.2 region have implicated primarily three genes: proline dehydrogenase (PRODH), ZDHHC8 and catechol-O-methyltransferase (COMT) [21]–[25] and their interactions [26], [27], a study by Liu et al. [22] presented suggestive evidence that common variants located at the 3?
catechol-O-methyltransferase Binding (interactions) of PRODH associated with catechol-o-methyltransferase and schizophrenia
1) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.85 Pain Relevance 0.13
Although, collectively, the human genetic and animal model studies designed to identify schizophrenia susceptibility genes from the 22q11.2 region have implicated primarily three genes: proline dehydrogenase (PRODH), ZDHHC8 and catechol-O-methyltransferase (COMT) [21]–[25] and their interactions [26], [27], a study by Liu et al. [22] presented suggestive evidence that common variants located at the 3?
COMT Binding (interactions) of PRODH associated with catechol-o-methyltransferase and schizophrenia
2) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.85 Pain Relevance 0.13

General Comments

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