INT216041

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnfrsf1b) cell death (Tnfrsf1b) endoplasmic reticulum (Rtn4r)
plasma membrane (Rtn4r) nucleus (Tnfrsf1b)
Anatomy Link Frequency
stalk 1
Tnfrsf1b (Mus musculus)
Rtn4r (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 92.48 High High
Central nervous system 10 83.12 Quite High
Eae 14 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 2 5.00 Very Low Very Low Very Low
Pain threshold 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 99.00 Very High Very High Very High
Necrosis 2 98.76 Very High Very High Very High
Depression 10 92.48 High High
Schizophrenia 124 76.64 Quite High
Injury 6 75.28 Quite High
Disease 22 68.36 Quite High
Heart Defects 2 35.92 Quite Low
Digeorge Syndrome 2 31.60 Quite Low
Cognitive Disorder 16 26.24 Quite Low
Congenital Anomalies 8 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other non-synonymous variant we identified in one male patient, L347R, is positioned within the “stalk” of RTN4R that is required for p75 interaction.


p75 Binding (interaction) of RTN4R in stalk
1) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.34 Pain Relevance 0.05
RTN4R, a glycosylphosphatidylinositol-linked (GPI-linked) cell surface molecule, forms a heteromeric receptor complex with either LINGO-1 and p75, or LINGO-1 and TROY (a tumor necrosis factor (TNF) receptor family member).
p75 Binding (complex) of RTN4R associated with necrosis and cancer
2) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

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