INT21606

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.90
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 4
hypothalamus 3
cerebral cortex 3
liver 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tramadol 16 99.98 Very High Very High Very High
anesthesia 4 98.92 Very High Very High Very High
tolerance 3 98.68 Very High Very High Very High
cerebral cortex 4 98.08 Very High Very High Very High
mu opioid receptor 10 93.84 High High
agonist 2 92.84 High High
Serotonin 2 92.36 High High
qutenza 4 88.72 High High
adenocard 2 85.80 High High
Clonidine 3 83.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 59 100.00 Very High Very High Very High
Insulin Resistance 11 100.00 Very High Very High Very High
Hyperinsulinism 1 100.00 Very High Very High Very High
Impaired Glucose Tolerance 3 98.68 Very High Very High Very High
Stroke 2 85.96 High High
Cognitive Disorder 10 85.32 High High
INFLAMMATION 53 81.24 Quite High
Body Weight 5 76.76 Quite High
Drug Induced Neurotoxicity 6 75.44 Quite High
Demyelinating Disease 1 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with either yohimbine or efaroxan reduced the plasma glucose level and increased the plasma insulin level of non-diabetic control and type-II diabetic rats but not of type-I diabetic rats.
Neg (not) Positive_regulation (increased) of Neg (not) Regulation (control) of insulin in plasma associated with diabetes mellitus
1) Confidence 0.41 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11712871 Disease Relevance 0.92 Pain Relevance 0.29
Further, when administered to overtly diabetic rats at 19 weeks of age, resiniferatoxin markedly improved glucose tolerance at two weeks after administration and this was accompanied by an increased insulin response to oral glucose as well as a reduction in the plasma levels of dipeptidyl peptidase IV.
Positive_regulation (increased) of Regulation (response) of insulin in plasma associated with diabetes mellitus, tolerance, hyperinsulinism and impaired glucose tolerance
2) Confidence 0.36 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15733558 Disease Relevance 0.84 Pain Relevance 0.39
Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats.
Positive_regulation (enhances) of Regulation (sensitivity) of insulin in cerebral cortex associated with tramadol and cerebral cortex
3) Confidence 0.36 Published 2005 Journal Brain Res. Bull. Section Title Doc Link 16140165 Disease Relevance 0.09 Pain Relevance 0.91
Subsequent bilateral electrical cervical vagal stimulation-induced insulin and glucagon responses in the same animals under anesthesia showed the same branch dependency.
Positive_regulation (induced) of Regulation (responses) of insulin associated with anesthesia
4) Confidence 0.27 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2178454 Disease Relevance 0 Pain Relevance 0.10
Identification of vagal preganglionics that mediate cephalic phase insulin response.
Positive_regulation (mediate) of Regulation (response) of insulin
5) Confidence 0.27 Published 1990 Journal Am. J. Physiol. Section Title Doc Link 2178454 Disease Relevance 0 Pain Relevance 0
Tramadol enhances hepatic insulin sensitivity via enhancing insulin signaling cascade in the cerebral cortex and hypothalamus of 90% pancreatectomized rats.
Positive_regulation (enhances) of in hypothalamus Regulation (sensitivity) of insulin in cerebral cortex associated with tramadol and cerebral cortex
6) Confidence 0.12 Published 2005 Journal Brain Res. Bull. Section Title Doc Link 16140165 Disease Relevance 0.09 Pain Relevance 0.91
In the studies presented here, the hypothalamus appears to play a key role in mediating the effects on hepatic insulin sensitivity in response to the administration of both central and peripheral HN and its analogs.
Positive_regulation (mediating) of Regulation (sensitivity) of insulin in hypothalamus
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.07 Pain Relevance 0.03
Interestingly a novel HN analog termed HNGF6A, which we created by combining both changes at position 6 and 14, dramatically increases its ability to modulate insulin action and offers a mode of administration that is more clinically applicable.
Positive_regulation (increases) of Regulation (modulate) of insulin
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.73 Pain Relevance 0.04
AMPK is known to regulate glucose transport [47] and its metabolism [48], lower blood pressure, boost liver insulin action [49], ameliorate insulin resistance induced by free fatty acids [18], and regulate protein synthesis [50] and forkhead transcription factor FKHR (FOXO1a) [51].
Positive_regulation (induced) of Regulation (resistance) of insulin in liver associated with insulin resistance
9) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.17 Pain Relevance 0.30

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