INT21609

Context Info Confidence 0.50 First Reported 1990 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 58 Total Number 59 Disease Relevance 40.78 Pain Relevance 5.47

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency lung 3 monocyte 2 spinal cord 2 thyroid 1 HeLa 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 310 99.96 Pain 17 99.78 alcohol 10 99.34 Spinal cord 23 99.28 cytokine 78 98.08 chemokine 3 97.52 ischemia 135 97.28 cINOD 33 94.80 qutenza 11 94.76 Central nervous system 4 92.64

Disease Link Frequency Relevance Heat Lung Cancer 266 100.00 Canker Sores 13 100.00 Sepsis 491 99.98 INFLAMMATION 357 99.96 Atherosclerosis 257 99.92 Pancreatitis 74 99.68 Volume Depletion And Dehydration 4 99.68 Pancreatic Cancer 30 99.66 Coronary Heart Disease 18 99.58 Cancer 1214 99.56

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Clinical evaluation of the patient requires correct diagnosis of RAS and classification of the disease based on morphology (MiAU, MjAU, HU) and severity (simple versus complex).

Positive_regulation (requires) of RAS associated with disease and canker sores

1) Confidence 0.50 Published 1997 Journal Semin Cutan Med Surg Section Abstract Doc Link 9421219 Disease Relevance 1.47 Pain Relevance 0.13

This association raises the possibility that sepsis stimulates RAS, which contributes to microvascular perfusion heterogeneity (manifested as impaired response to local ischemia), and that perfusion heterogeneity contributes to organ failure.

Positive_regulation (stimulates) of RAS associated with cv general 4 under development, ischemia and sepsis

2) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.11 Pain Relevance 0.10

Although we did identify a relationship between arterial hypotension and circulating Ang II after the first day of severe sepsis, the modest statistical significance and lack of a similar relationship between hypotension and PRA (a biologic precursor to Ang II) temper our enthusiasm to declare arterial pressure a dominant factor leading to persistent RAS activation during sepsis.

Positive_regulation (activation) of RAS associated with pressure volume 2 under development and sepsis

3) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.26 Pain Relevance 0.08

We note that the levels of PRA and Ang II measured in our septic subjects are elevated nearly two-fold compared to outpatients with risk factors for vascular disease [33,34], arguing that the acute septic state contributes to RAS activation.

Positive_regulation (activation) of RAS associated with increased venous pressure under development

4) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.23 Pain Relevance 0.03

Similarly, preexisting hypertension, diabetes, and coronary disease are associated with increased RAS activity, and no doubt are co-morbid conditions in clinical sepsis.

Positive_regulation (increased) of RAS associated with diabetes mellitus, hypertension, coronary heart disease and sepsis

5) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.04 Pain Relevance 0.03

Circulating mediators of RAS were measured and compared to both microvascular responses during reactive hyperemia as well as to organ dysfunction.

Positive_regulation (mediators) of RAS associated with hyperemia

6) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.98 Pain Relevance 0.07

We considered that RAS activation might simply reflect glomerular hypoperfusion due to hypovolemia, hypotension, or insufficient resuscitation.

Positive_regulation (activation) of RAS associated with pressure volume 2 under development

7) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.62 Pain Relevance 0.08

The renin-angiotensin system (RAS) is activated in sepsis, and recent studies implicate Ang II in the pathogenesis of acute lung injury in animal models [14].

Positive_regulation (activated) of RAS in lung associated with adult respiratory distress syndrome and sepsis

8) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.95 Pain Relevance 0.07

We cautiously note that our studies do not define a causal role of RAS in the pathogenesis of septic microvascular dysfunction, and RAS activation may be unrelated or even compensatory for microvascular dysfunction.

Positive_regulation (activation) of RAS

9) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.93 Pain Relevance 0.12

We hypothesize that RAS activation is associated with impaired microvascular regulation and organ dysfunction in patients with sepsis.

Positive_regulation (activation) of RAS associated with sepsis

10) Confidence 0.41 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.05 Pain Relevance 0.09

Since elevated activation of the RAS signaling pathway, including overexpression of HER-2/neu and mutations of RAS and BRAF, is common in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression status of OPCML in a genetically defined human ovarian cancer model.

Spec (examined) Positive_regulation (activation) of RAS associated with ovarian cancer

11) Confidence 0.41 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.47 Pain Relevance 0.09

The key question for future research on the matter should be: are results in CES or RAS improved by adding haptic feedback?

Positive_regulation (results) of RAS

12) Confidence 0.40 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Further results, which indicate the huge value of three-dimensional vision restoration that occurs in RAS, also seem logical.

Positive_regulation (occurs) of RAS

13) Confidence 0.38 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Their response to RAs at the cellular level was also evaluated.

Positive_regulation (response) of RAs

14) Confidence 0.31 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2766466 Disease Relevance 0.62 Pain Relevance 0.05

There was no relationship between serum creatinine and either measure of RAS activation.

Positive_regulation (activation) of RAS

15) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.49 Pain Relevance 0.03

RAS is activated in clinical severe sepsis.

Positive_regulation (activated) of RAS associated with sepsis

16) Confidence 0.27 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2875539 Disease Relevance 0.63 Pain Relevance 0.03

Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation.

Positive_regulation (induction) of ras in spinal cord associated with pain and spinal cord

17) Confidence 0.21 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9149109 Disease Relevance 0 Pain Relevance 0.24

We report here using Northern blot analysis with these cDNA probes that noxious stimulation causes a marked and coincident increase in rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord.

Positive_regulation (increase) of ras in spinal cord associated with spinal cord

18) Confidence 0.21 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9149109 Disease Relevance 0 Pain Relevance 0.13

Further studies analyzing non-ACE pathways contributing to RAS activity in human pancreatic disorders are needed.

Positive_regulation (contributing) of RAS

19) Confidence 0.20 Published 2008 Journal Hepatogastroenterology Section Body Doc Link 19102399 Disease Relevance 0.05 Pain Relevance 0

Neurohormonal activation, primarily of the sympathetic nervous system and the RAS, counteracts myocardial dysfunction initially, but may eventually aggravate the underlying pathophysiology, causing a further deterioration of cardiac function.

Positive_regulation (activation) of RAS in sympathetic nervous system associated with coronary heart disease

20) Confidence 0.20 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.02 Pain Relevance 0.08

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