INT2161

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Context Info
Confidence 0.73
First Reported 1979
Last Reported 2008
Negated 3
Speculated 3
Reported most in Abstract
Documents 33
Total Number 36
Disease Relevance 0.87
Pain Relevance 14.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
anterior lobe 4
median eminence 4
hypothalamus 2
follicle 2
gonadotrophs 2
Gnrh1 (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 70 100.00 Very High Very High Very High
Neuropeptide 43 99.72 Very High Very High Very High
ketamine 27 99.66 Very High Very High Very High
agonist 27 99.62 Very High Very High Very High
gABA 19 99.46 Very High Very High Very High
substance P 34 99.22 Very High Very High Very High
antagonist 72 98.80 Very High Very High Very High
Enkephalin 26 98.64 Very High Very High Very High
Dopamine 15 98.48 Very High Very High Very High
opiate 2 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 57 87.00 High High
Reprotox - General 3 2 78.72 Quite High
Infection 4 75.00 Quite High
Anovulation 1 62.92 Quite High
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to determine 1) whether the changes in GnRH-induced LH secretion in DES-exposed castrated rats are partially attributable to a direct effect of ketamine; 2) the gender-specific effects of ketamine on LH secretion; and 3) the DES-dependent effects of ketamine on LH secretion.
GnRH Spec (whether) Positive_regulation (induced) of Localization (secretion) of LH associated with ketamine
1) Confidence 0.73 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485248 Disease Relevance 0 Pain Relevance 0.73
To explore whether a common mechanism may underlie inhibition of gonadotropin secretion by various stressors, we examined in the present study the effect of lipopolysaccharide (LPS) on LH release induced by progesterone, GnRH, naloxone and NMDA.
GnRH Spec (examined) Positive_regulation (induced) of Localization (release) of LH associated with narcan
2) Confidence 0.68 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.23 Pain Relevance 0.23
F inhibited GnRH-induced secretion of LH without affecting secretion of FSH.
GnRH Positive_regulation (induced) of Localization (secretion) of LH
3) Confidence 0.56 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3129945 Disease Relevance 0 Pain Relevance 0.09
It is not known what impact ketamine has on baseline LH levels or on GnRH-stimulated LH release in estrogen-exposed castrated rats.
GnRH Positive_regulation (stimulated) of Localization (release) of LH associated with ketamine
4) Confidence 0.53 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485248 Disease Relevance 0 Pain Relevance 0.65
Toxic effects of cadmium on LHRH-induced LH release and ovulation in rats.
LHRH Positive_regulation (induced) of Localization (release) of LH
5) Confidence 0.53 Published 1991 Journal Reprod. Toxicol. Section Title Doc Link 1807553 Disease Relevance 0.06 Pain Relevance 0.15
DSLET inhibited only the GnRH-induced release of LH.
GnRH Positive_regulation (induced) of Localization (release) of LH
6) Confidence 0.52 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7616159 Disease Relevance 0 Pain Relevance 0.80
Pretreatment with LPS, which did not affect basal LH release or GnRH-induced LH release, inhibited naloxone-induced and NMDA-induced LH release.
GnRH Neg (not) Positive_regulation (induced) of Localization (release) of LH associated with narcan
7) Confidence 0.49 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.20 Pain Relevance 0.35
Pretreatment with LPS, which did not affect basal LH release or GnRH-induced LH release, inhibited naloxone-induced and NMDA-induced LH release.
GnRH Neg (not) Positive_regulation (induced) of Localization (release) of LH associated with narcan
8) Confidence 0.49 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.20 Pain Relevance 0.35
It is not known what impact ketamine has on baseline LH levels or on GnRH-stimulated LH release in estrogen-exposed castrated rats.
GnRH Positive_regulation (stimulated) of Localization (release) of LH associated with ketamine
9) Confidence 0.46 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485248 Disease Relevance 0 Pain Relevance 0.65
A significant inhibition of GnRH- or naloxone-induced release of LH is obtained when rats are pretreated for 0, 15, 30 or 60 min with 5,000 ng/100 g BW of GnRH antagonist but no inhibition is evident when the antagonist is injected 180 min before either stimulant of LH secretion.
GnRH Positive_regulation (induced) of Localization (release) of LH associated with antagonist and narcan
10) Confidence 0.43 Published 1982 Journal Neuroendocrinology Section Abstract Doc Link 6755289 Disease Relevance 0 Pain Relevance 0.66
Gonadotropin-releasing hormone (GnRH) and oxytocin both stimulate the secretion of luteinizing hormone (LH), although with different characteristics.
GnRH Positive_regulation (stimulate) of Localization (secretion) of LH
11) Confidence 0.42 Published 1995 Journal Peptides Section Abstract Doc Link 7716067 Disease Relevance 0 Pain Relevance 0.07
Gonadotropin-releasing hormone (GnRH) and oxytocin both stimulate the secretion of luteinizing hormone (LH), although with different characteristics.
Gonadotropin-releasing hormone Positive_regulation (stimulate) of Localization (secretion) of LH
12) Confidence 0.42 Published 1995 Journal Peptides Section Abstract Doc Link 7716067 Disease Relevance 0 Pain Relevance 0.07
However, the same melatonin treatment did not inhibit the NMDA-induced or LHRH-induced LH secretion.
LHRH Positive_regulation (induced) of Localization (secretion) of LH
13) Confidence 0.39 Published 1999 Journal Endocr. J. Section Abstract Doc Link 10724360 Disease Relevance 0 Pain Relevance 0.45
Intraventricular injection of melatonin inhibits naloxone-induced, but not NMDA- or LHRH-induced LH release in ovariectomized estrogen-primed rats.
LHRH Positive_regulation (induced) of Localization (release) of LH associated with narcan
14) Confidence 0.39 Published 1999 Journal Endocr. J. Section Title Doc Link 10724360 Disease Relevance 0 Pain Relevance 0.57
In this study we also compared spontaneous and GnRH-induced LH release by anterior and entire pituitaries and found that the amount of LH released by the anterior lobe was twofold higher, suggesting that inhibitory factors present in the neurointermediate part may affect the release of LH.
GnRH Positive_regulation (induced) of Localization (released) of LH in anterior lobe
15) Confidence 0.38 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7616159 Disease Relevance 0 Pain Relevance 0.73
DAGO inhibited dose-dependently the spontaneous and GnRH-induced release of LH.
GnRH Positive_regulation (induced) of Localization (release) of LH
16) Confidence 0.38 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7616159 Disease Relevance 0 Pain Relevance 0.79
In this study we also compared spontaneous and GnRH-induced LH release by anterior and entire pituitaries and found that the amount of LH released by the anterior lobe was twofold higher, suggesting that inhibitory factors present in the neurointermediate part may affect the release of LH.
GnRH Positive_regulation (induced) of Localization (release) of LH in anterior lobe
17) Confidence 0.38 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7616159 Disease Relevance 0 Pain Relevance 0.73
Neither GABA agonist had any effect on LHRH-stimulated LH release in vivo, suggesting that their effect was specific and achieved at the level of the CNS.
LHRH Positive_regulation (stimulated) of Localization (release) of LH associated with gaba and agonist
18) Confidence 0.35 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1335551 Disease Relevance 0 Pain Relevance 0.67
Multiple injections with naloxone failed to affect basal LH concentrations but did result in a decrease in GnRH-stimulated LH secretion in ovariectomized nonreproductive and reproductive females.
GnRH Positive_regulation (stimulated) of Localization (secretion) of LH associated with narcan
19) Confidence 0.34 Published 2002 Journal Horm Behav Section Abstract Doc Link 11855897 Disease Relevance 0.08 Pain Relevance 0.37
Nitrendipine (Ntd, 1 microM) produced 35-50% inhibition (NS) of both FSH and LH release stimulated by either 50 mM K+ or 100 nM GnRH.
GnRH Positive_regulation (stimulated) of Localization (release) of LH
20) Confidence 0.32 Published 1990 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 2170211 Disease Relevance 0 Pain Relevance 0.17

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