INT216105

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 2.55
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dmd) cytoskeleton (Dmd) nucleus (Dmd)
cytoplasm (Dmd)
Anatomy Link Frequency
muscles 2
brain 2
internal 2
muscle fibers 2
Dmd (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 97.24 Very High Very High Very High
palliative 2 89.96 High High
potassium channel 6 78.48 Quite High
Neurotransmitter 46 74.84 Quite High
Potency 6 73.36 Quite High
ischemia 4 58.96 Quite High
Neuronal nitric oxide synthase 2 56.72 Quite High
Glutamate 7 8.32 Low Low
gABA 1 7.20 Low Low
Hippocampus 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 24 99.54 Very High Very High Very High
Necrosis 7 96.48 Very High Very High Very High
Muscle Weakness 2 95.52 Very High Very High Very High
Muscular Dystrophy 169 95.48 Very High Very High Very High
Mental Disorders 2 93.96 High High
Disease 19 88.28 High High
Body Weight 8 78.16 Quite High
Disease Progression 2 74.96 Quite High
Intellectual Impairment 14 73.76 Quite High
Congenital Anomalies 25 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the distribution of VGSCs, and to test whether the absence of dystrophin influences Na+ channel gating properties via syntrophin, we performed confocal imaging of mdx5cv and control fibers labeled with an anti-SkM1 monoclonal antibody against Nav1.4, and a polyclonal antiserum against ?
Spec (whether) Regulation (influences) of Neg (absence) Gene_expression (absence) of dystrophin associated with imagery
1) Confidence 0.36 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.08
Myostatin inhibition resulted in a significant decrease in serum CK levels in the mdx 4H group compared to age matched control mdx levels (Fig. 4B); however, serum CK levels in the mdx 11L and 11H groups did not differ from eleven month old control mdx levels.
Neg (not) Regulation (differ) of Gene_expression (levels) of mdx
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.37 Pain Relevance 0
It has three upstream promoters that control expression of full-length dystrophin Dp427 and four internal promoters which regulate expression of the short dystrophin isoforms, Dp260, Dp140, Dp116, and Dp71 (reviewed at www.dmd.nl; Table 1; Textbox 1 in “Appendix”).
Regulation (control) of Gene_expression (expression) of dystrophin in internal associated with muscular dystrophy
3) Confidence 0.24 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 1.26 Pain Relevance 0.09
This finding raises the possibility that there may be more patients with cognitive impairments caused by alterations in dystrophin expression or function and demonstrates the important role for dystrophin and its associated proteins in the brain (reviewed by [25]).
Regulation (alterations) of Gene_expression (expression) of dystrophin in brain associated with cognitive disorder
4) Confidence 0.24 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.65 Pain Relevance 0.07
Taken together, the current results suggest that PEG-PEI copolymers enhance dystrophin expression and that repeat injections are more effective at transfecting a greater number of muscle fibers than individual injections containing about the same amount of ESO.
Regulation (effective) of Gene_expression (expression) of dystrophin in muscle fibers
5) Confidence 0.17 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0
As expected, dystrophin expression in control mdx muscles was not detectable, and was likely less than 1% of normal.
Regulation (control) of Gene_expression (expression) of dystrophin in muscles
6) Confidence 0.17 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0.05 Pain Relevance 0.04
Micro-dystrophin expression levels result in reduced mdx pathology
Regulation (result) of Gene_expression (levels) of Micro-dystrophin
7) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.10 Pain Relevance 0
Lastly, consistent with biological activity, micro-dystrophin levels were sufficient to restore proper localization of dystrophin-associated proteins (DAP) proteins ?
Regulation (sufficient) of Gene_expression (levels) of micro-dystrophin
8) Confidence 0.08 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0 Pain Relevance 0
The clustering and precise membrane localization of Kir4.1 and AQP4 are dependent on the dystrophin gene product, Dp71 [13]–[15].
Regulation (dependent) of Gene_expression (product) of dystrophin
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.11 Pain Relevance 0.14

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