INT216106

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.00
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 6
Imraq1 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 1 95.20 Very High Very High Very High
Pyramidal cell 40 87.44 High High
sodium channel 2 48.72 Quite Low
Inflammation 8 41.60 Quite Low
fibrosis 2 19.00 Low Low
imagery 23 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
GABAergic 11 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
interneuron 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 10 95.84 Very High Very High Very High
Sclerosis 4 92.92 High High
Disease Progression 4 83.64 Quite High
Muscular Dystrophy 47 83.20 Quite High
Neuropathic Pain 2 77.80 Quite High
Charcot Marie Tooth Disease 8 77.12 Quite High
Congenital Structural Myopathies 34 75.52 Quite High
Tauopathy 40 73.56 Quite High
Targeted Disruption 45 72.00 Quite High
Demyelinating Disease 4 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
rAAV1, 6, or 8.MCK.micro-dystrophin vector was perfused (100 ?
Positive_regulation (perfused) of Gene_expression (vector) of rAAV1
1) Confidence 0.05 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.06 Pain Relevance 0
We characterized the time course and stability of GFP expression after AAV transfection in Pv-cre mice.
Positive_regulation (transfection) of Gene_expression (transfection) of AAV
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0 Pain Relevance 0.14
Sweeney) and a similar loss of AAV mediated myostatin propeptide expression after six weeks in the highly regenerative alpha-sarcoglycan null model [20], [21].
Positive_regulation (mediated) of Gene_expression (expression) of AAV
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.15 Pain Relevance 0
Qiao et al. recently reported that the AAV mediated expression of a mutated myostatin propeptide increases muscle size and improves pathology in mdx animals [14].
Positive_regulation (mediated) of Gene_expression (expression) of AAV in muscle
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.70 Pain Relevance 0
Confocal microscopic examination of AAV transduced muscle overexpressing myotubularin revealed considerably stronger signal at the triads and specific localization at the sarcolemma as well.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of AAV in muscle
5) Confidence 0.01 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.06 Pain Relevance 0
The abnormal membrane structures observed upon AAV-mediated myotubularin overexpression in muscle could result from an imbalance between membrane internalization and recycling during endocytosis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AAV in muscle
6) Confidence 0.01 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2441725 Disease Relevance 0.51 Pain Relevance 0
A recent study described wild-type tau to mediate some neurodegeneration with combined microgliosis by AAV gene-transfer [42].
Positive_regulation (transfer) of Gene_expression (transfer) of AAV
7) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.52 Pain Relevance 0.05

General Comments

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