INT216108

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.32
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dmd) cytoskeleton (Dmd) nucleus (Dmd)
cytoplasm (Dmd)
Anatomy Link Frequency
muscle 8
patterning 2
Dmd (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 23 98.72 Very High Very High Very High
Neurotransmitter 66 91.20 High High
Potency 15 87.36 High High
fibrosis 37 5.00 Very Low Very Low Very Low
Hippocampus 36 5.00 Very Low Very Low Very Low
Central nervous system 24 5.00 Very Low Very Low Very Low
GABAergic 24 5.00 Very Low Very Low Very Low
imagery 22 5.00 Very Low Very Low Very Low
Glutamate receptor 18 5.00 Very Low Very Low Very Low
amygdala 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 43 99.50 Very High Very High Very High
Targeted Disruption 61 99.44 Very High Very High Very High
Coronary Heart Disease 8 96.16 Very High Very High Very High
Increased Venous Pressure Under Development 11 84.64 Quite High
Cardiomyopathy 63 84.56 Quite High
Rupture 3 82.12 Quite High
Muscular Dystrophy 387 76.20 Quite High
Lifespan 11 33.84 Quite Low
Cognitive Disorder 36 32.48 Quite Low
Attention Deficit Hyperactivity Disorder 7 27.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, muscle degeneration was observed in larvae, when all dystrophin isoform expression levels, or Dp117 specifically, were reduced in muscle by transgenic RNA interference [37].
Negative_regulation (reduced) of Gene_expression (expression) of dystrophin in muscle associated with targeted disruption
1) Confidence 0.45 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.22 Pain Relevance 0.05
These abnormalities were also observed when expression of dystroglycan or different isoforms of dystrophin (all isoforms, DLP1-3, or the smaller isoforms only) were reduced by RNA interference either in the photoreceptor axons or the glia, suggesting that both cell types are required for wild-type axon patterning.
Negative_regulation (reduced) of Gene_expression (expression) of dystrophin in patterning associated with congenital anomalies
2) Confidence 0.38 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.18 Pain Relevance 0
9 M had no significant effect on control muscles, it produced a significant reduction of Na+ entry in mdx5cv muscles (30%, Fig. 1).
Negative_regulation (reduction) of Gene_expression (muscles) of mdx5cv in muscles
3) Confidence 0.34 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.29
In adult flies, progressive muscle degeneration and impaired climbing ability were observed when dystrophin or dystroglycan expression was reduced [21].
Negative_regulation (reduced) of Gene_expression (expression) of dystrophin in muscle
4) Confidence 0.33 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.15 Pain Relevance 0.04
6, denoted mdx 11L) or one month of age (n?
Negative_regulation (denoted) of Gene_expression (11L) of mdx
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.05 Pain Relevance 0
Even with this short term treatment regime and the resultant decline in the expression of the dystrophin gene by 12 weeks after treatment had finished, to less than 1% of the original expression level, the cardiac improvement continued for up to 7 months [85, 86].
Negative_regulation (decline) of Gene_expression (expression) of dystrophin gene
6) Confidence 0.21 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.49 Pain Relevance 0
g of ESO produced over 1200 dystrophin positive fibers and 20% of normal levels of dystrophin expression.
Negative_regulation (levels) of Gene_expression (expression) of dystrophin
7) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0
Western analysis of dystrophin expression
Negative_regulation (analysis) of Gene_expression (expression) of dystrophin
8) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0
However, there was exceptionally high variability in dystrophin expression within the 10 ?
Negative_regulation (was) of Gene_expression (expression) of dystrophin
9) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0.04
The dystrophin expression achieved in the present study was accomplished with PEG-PEI carriers that did not appear to elicit any overt signs of cytotoxicity.
Negative_regulation (accomplished) of Gene_expression (expression) of dystrophin
10) Confidence 0.16 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0
The dystrophin expression after 50 ?
Negative_regulation (The) of Gene_expression (expression) of dystrophin
11) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2362111 Disease Relevance 0 Pain Relevance 0.04
Widespread micro-dystrophin expression was observed in the TA and EDL muscles of mice receiving rAAV6 and rAAV8 at all three time points (Fig. 1B).
Negative_regulation (observed) of Gene_expression (expression) of micro-dystrophin in muscles
12) Confidence 0.07 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.24 Pain Relevance 0

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