INT21611

Context Info Confidence 0.35 First Reported 1984 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 20 Total Number 20 Disease Relevance 11.76 Pain Relevance 2.15

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

Anatomy Link Frequency plasma 1 lymphocytes 1 colon 1 nerve 1 T29H 1 RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 10 98.28 Inflammation 19 97.92 fibrosis 14 97.24 opiate 6 97.08 agonist 3 96.80 hyperexcitability 7 96.76 Chronic pancreatitis 25 96.00 backache 1 91.40 headache 1 90.96 Enkephalin 1 90.32

Disease Link Frequency Relevance Heat Colon Cancer 29 100.00 Disorder Of Lipid Metabolism 7 100.00 Nervous System Injury 2 99.40 Fibrosis 14 99.32 Pancreatic Cancer 34 99.12 Toxicity 9 99.00 Cancer 592 98.42 Bordatella Infection 2 98.34 INFLAMMATION 24 97.92 Sepsis 44 96.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The loss of force feedback in RAS compared with CES may be balanced partly by the restoration of three-dimensional vision.

Negative_regulation (loss) of RAS

1) Confidence 0.35 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2686803 Disease Relevance 0 Pain Relevance 0

Furthermore, suppression of oncogenic RAS activity by stable siRNA specific for HRAS(V12) led to the demethylation and re-expression of OPCML in T29H cells, demonstrating that oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML.

Negative_regulation (suppression) of oncogenic RAS in T29H

2) Confidence 0.34 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.36 Pain Relevance 0.06

Importantly, our studies provide an impetus to determine if pharmacologic RAS blockade can increase microvascular function and improve septic patient outcomes.

Negative_regulation (blockade) of RAS

3) Confidence 0.22 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.72 Pain Relevance 0.03

Besides, ATRA downregulation of Ras and Bcl2 was shown to correlate with the activation of let-7a miRNA [12].

Negative_regulation (downregulation) of Ras

4) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.60 Pain Relevance 0

Recently, Garzon et al. showed that all-trans retinoic acid (ATRA) downregulation of Bcl2 and Ras was correlated with the activation of miR-15a/miR-16-1 [12].

Negative_regulation (downregulation) of Ras

5) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.17 Pain Relevance 0

The blockade of Ras binding to the plasma membrane may therefore be a good therapeutic target for the treatment of malignancies [22].

Negative_regulation (blockade) of Ras in plasma

6) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.28 Pain Relevance 0.05

Akao et al. found that the levels of Ras and c-Myc proteins in let-7 miRNA low-expressing DLD-1 human colon cancer cells were lowered after the transfection with let-7a-1 precursor miRNA, whereas the levels of both of their mRNAs remained almost unchanged.

Negative_regulation (lowered) of Ras in colon associated with colon cancer

7) Confidence 0.09 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 0.73 Pain Relevance 0

Likewise, in our study, high expression of Ras inhibitor 1 (RIN1) and low expression of Ras-like without CAAX1 (RIT1) were associated with better overall survival, which is in agreement with previous work by others showing that activated Ras contributes to the maintenance and growth of ovarian carcinomas [38].

Negative_regulation (inhibitor) of Ras associated with ovarian cancer

8) Confidence 0.07 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.62 Pain Relevance 0

Aliskiren belongs to a new class of agents that effectively and specifically inhibit the RAS.

Negative_regulation (inhibit) of RAS

9) Confidence 0.07 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19066408 Disease Relevance 0.43 Pain Relevance 0.22

In these tumors, it negatively influences mitogenic signal transduction of growth factors and blocks ras activity.

Negative_regulation (blocks) of ras associated with cancer

10) Confidence 0.07 Published 2001 Journal Lab. Invest. Section Abstract Doc Link 11406647 Disease Relevance 1.01 Pain Relevance 0

This gene plays a role in the indirect suppression of Ras activity resulting in the inhibition of cell growth.

Negative_regulation (suppression) of Ras

11) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.60 Pain Relevance 0

Experiments two and three showed that ACE inhibition effectively reduced alcohol drinking faster in animals with elevated RAS activity and not at all in animals with suppressed RAS activity indicating that initial levels of RAS activity may determine the speed and ability of ACE inhibition to attenuate alcohol intake.

Negative_regulation (suppressed) of RAS associated with alcohol

12) Confidence 0.05 Published 1990 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 2178480 Disease Relevance 0.20 Pain Relevance 0.63

Additionally, transfection of HepG2 cells with a let-7a precursor resulted in about 70% reduction of RAS.

Negative_regulation (reduction) of RAS

13) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.53 Pain Relevance 0

However, no consistent decrease in H-ras mRNA, levels, in peripheral blood lymphocytes, was observed [85].

Neg (no) Negative_regulation (decrease) of H-ras mRNA in lymphocytes

14) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.69 Pain Relevance 0.03

Adenovirus-p53) gene-specific ribozymes, which are able to break down specific RNA sequences, or with antisense oligonucleotides, (2) small molecule inhibition of receptor tyrosine kinases, (3) inhibition of p21(ras) farnesylation either by inhibition of farnesyl transferase or synthesis inhibition of farnesyl moieties, and (4) specific antibody approaches (e.g. anti-HER2 or anti-VEGF).

Negative_regulation (inhibition) of ras

15) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.61 Pain Relevance 0

Thus, it still remains elusive, if the combination of chemotherapy, Mcl-1 RNAi and inhibitors of the Ras/Raf/MEK/ERK pathway is more efficient than the treatment with chemotherapy and Mcl-1 RNAi alone.

Negative_regulation (inhibitors) of Ras

16) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.09 Pain Relevance 0

Bordetella pertussis toxin (PT) catalyzes the ADP-ribosylation of a 41,000-Da peptide believed to be a subunit of the putative guanyl nucleotide-binding protein (Gi) involved in cyclase inhibition and abolishes inhibitory effects of opiate agonists.

Negative_regulation (subunit) of guanyl nucleotide-binding protein associated with bordatella infection, agonist and opiate

17) Confidence 0.01 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6319376 Disease Relevance 0.36 Pain Relevance 0.42

We examined the relation between specific single nucleotide polymorphisms (SNPs), including those in the RAS, apolipoprotein E and alpha-adducin, and renal function decline assessed by estimated glomerular filtration rate (eGFR) over an 11-year period in 2578 Caucasian participants of the Nurses' Health Study.

Negative_regulation (decline) of RAS associated with disorder of lipid metabolism

18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2650781 Disease Relevance 0.28 Pain Relevance 0

Recent studies have shown that ACE enzyme directs pancreatic fibrogenesis in experimental animals [33] and inhibition of the RAS system with an ACE inhibitor attenuates pancreatic inflammation and fibrosis in an animal model of chronic pancreatitis [22].

Negative_regulation (inhibition) of RAS associated with fibrosis, inflammation and chronic pancreatitis

19) Confidence 0.01 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.15 Pain Relevance 0.39

We used inhibitors of nitric oxide synthase, soluble guanyl cyclase, or PKG after nerve injury, and found that each prevented the appearance of the LTH.

Negative_regulation (inhibitors) of guanyl cyclase in nerve associated with nervous system injury and hyperexcitability

20) Confidence 0.00 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15329406 Disease Relevance 0.35 Pain Relevance 0.31

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